ChemicalBook > Product Catalog > Organic Chemistry > Hydrocarbons and derivatives > Hydrocarbon nitrification > 1-Chloroethyl (4-nitrophenyl) carbonate
1-Chloroethyl (4-nitrophenyl) carbonate
1-Chloroethyl (4-nitrophenyl) carbonate Basic information
- Product Name:
- 1-Chloroethyl (4-nitrophenyl) carbonate
- Synonyms:
-
- Carbonic acid 4-nitro-phenyl ester 1-chloro-ethyl ester
- 1-Chloroethyl (4-nitrophenyl) carbonate
- 1-Chloroethyl p-nitrophenyl carbonate
- Carbonic acid, 1-chloroethyl 4-nitrophenyl ester
- Carbonic acid 1-chloro-ethyl ester 4-nitro-phenyl ester
- Carbonic acid 4-nitro-phenyl ester 1-chloro-ethyl ester ISO 9001：2015 REACH
- 1-Chloroethyl-4-nitrophenyl carbonate (1-CENPC)
- 1-Chloroethyl 4-nitrophenyl carbonat
- CAS:
- 101623-69-2
- MF:
- C9H8ClNO5
- MW:
- 245.62
- Mol File:
- 101623-69-2.mol
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1-Chloroethyl (4-nitrophenyl) carbonate Chemical Properties
- Melting point:
- 71.0-71.7 °C(Solv: hexane (110-54-3))
- Boiling point:
- 359.1±42.0 °C(Predicted)
- Density
- 1.415±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
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1-Chloroethyl (4-nitrophenyl) carbonate Usage And Synthesis
Uses
A clear, colourless to pale yellow liquid used as an intermediate in Gabapentin, an API.
Synthesis
To an ice cold reaction mixture containing p-nitrophenol (1.39 g, 10 mmol) and pyridine (0.81 g, 10 mmol) in dichloromethane (60 mL) was added 1-chloroethyl chloroformate (1.2 mL, 11 mmol). The mixture was stirred at 0° C for 30 min and then at room temperature for 1 hour. After removing the solvent under reduced pressure, the residue was dissolved in ether, washed with water, 10percent citric acid and water. The ether layer was dried over Na2SO4and evaporated under reduced pressure to give 2.4 g (97percent) of 1-Chloroethyl (4-nitrophenyl) carbonate as an off-white solid.
1-Chloroethyl (4-nitrophenyl) carbonateSupplier
Energy Chemical
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- 021-021-58432009 400-005-6266
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SuZhou ShiYa Biopharmaceuticals, Inc.
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- 86(512)5235 8471 17715136450
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SuZhou ShiYa Biopharmaceuticals, Inc.
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- 0512-52358471 17715136450
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Shijiazhuang Sdyano Fine Chemical Co., Ltd.
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- 0311-89250318 031166536426
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Amadis Chemical Company Limited
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