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8-Oxocoptisine

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8-Oxocoptisine Basic information

Product Name:
8-Oxocoptisine
Synonyms:
  • 8-Oxycoptisine
  • 8-Oxocoptisine
  • 4H-Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizin-4-one, 6,7-dihydro-
  • 8-Oxocoptisine,inhibit,Inhibitor,8 Oxocoptisine,8Oxocoptisine
  • 6,7-Dihydro-4H-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-4-one
  • Butyl Parahydroxybenzoate Impurity 6
  • 8-Oxocoptisine, 10 mM in DMSO
CAS:
19716-61-1
MF:
C19H13NO5
MW:
335.31
Mol File:
19716-61-1.mol
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8-Oxocoptisine Chemical Properties

Melting point:
283-285℃
Boiling point:
617.5±55.0 °C(Predicted)
Density 
1.61±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
-20°C
solubility 
Chloroform: soluble
form 
Cryst.
pka
-1.62±0.20(Predicted)
color 
Light yellow to yellow
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Safety Information

Toxicity
TDLo orl-rat: 1 mg/kg BIPBU* 24,1277,2001
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8-Oxocoptisine Usage And Synthesis

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the root of Thalictrum glandulosissimum.

Uses

8-Oxocoptisine is a natural protoberberine alkaloid with anti-cancer activity[1].

Safety Profile

A poison by ingestion.When heated to decomposition it emits toxic vapors of NOx.

References

[1] Ping Qian, et al. Five new alkaloids from Coptidis Rhizoma-Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cells. Fitoterapia. 2014 Mar;93:74-80. DOI:10.1016/j.fitote.2013.12.016

8-OxocoptisineSupplier

Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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Hangzhou Sage Chemical Co., Ltd.
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+86057186818502 13588463833
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Shanghai Tauto Biotech Co., Ltd.
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021-51320588
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Chengdu Herbpurify Co.Ltd.
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2355253622; 18981954830
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Shanghai Yongye Biotechnology Co., Ltd.
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86-021-61559134 15921386130
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3423497944@qq.com
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