Benzyl-PEG7-alcohol Chemical Properties

Boiling point:

508.4±45.0 °C(Predicted)

Density 

1.099±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

14.36±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C21H36O8/c22-6-7-23-8-9-24-10-11-25-12-13-26-14-15-27-16-17-28-18-19-29-20-21-4-2-1-3-5-21/h1-5,22H,6-20H2

InChIKey

ZCSFSTZVHMIOOJ-UHFFFAOYSA-N

SMILES

C(C1=CC=CC=C1)OCCOCCOCCOCCOCCOCCOCCO

Benzyl-PEG7-alcohol Usage And Synthesis

Description

Benzyl-PEG8-alcohol is a PEG linker including a benzyl protecting group, which can be deprotected under catalytic hydrogenation and reactive primary alcohol. The primary alcohol can react and further derivatize the compound. The hydrophilic PEG8 units bolster the aqueous media solubility of the compound. Please contact us for GMP-grade inquiries.

Uses

Benzyl-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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