2-broMo-3-Methyl-pyridine-3-carboxyl acid Chemical Properties

Boiling point:

373.9±42.0 °C(Predicted)

Density 

1.692±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

3.42±0.10(Predicted)

2-broMo-3-Methyl-pyridine-3-carboxyl acid Usage And Synthesis

Synthesis

The general procedure for the synthesis of 6-bromo-5-methyl-pyridine-2-carboxylic acid from 5-methyl-6-bromo-pyridine-2-carbonitrile was as follows: 6-bromo-5-methyl-pyridine-2-carbonitrile (1.0 g, 5.0 mmol) was dissolved in an aqueous solution of sodium hydroxide (0.3 g, 7 mmol, 20 mL), and the reaction was stirred at 120 °C overnight. Upon completion of the reaction, the reaction mixture was adjusted to pH=3 with acid and subsequently extracted with ethyl acetate (3 x 15 mL). The organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 6-bromo-5-methyl-pyridine-2-carboxylic acid (0.7 g, 63.8% yield). Mass spectrometry (EI) analysis showed m/e 216.0 [M+H]+.

References

[1] Patent: US2012/316147, 2012, A1. Location in patent: Page/Page column 52
[2] Patent: WO2012/168350, 2012, A1. Location in patent: Page/Page column 114

2-broMo-3-Methyl-pyridine-3-carboxyl acid(1211516-25-4)Related Product Information

• 2-BROMO-3-IODO-5-METHYLPYRIDINE
• 3-PYRIDINECARBOXYLIC ACID, 6-BROMO-5-CHLORO-
• 2-BroMo-3-chloroisonicotinaldehyde
• 2-Bromo-3-fluoro-4-formylpyridine
• 2-bromo-3-chloroisonicotinic acid
• 2-Bromo-3-iodo-5-(trifluoromethyl)pyridine
• 2-Bromo-3-chlorobenzonitrile
• 2-Bromo-3-fluoropyridin-4-ol
• 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine
• 2-BROMO-3-FLUORO-4-METHYLPYRIDINE
• 2-BROMO-6-CHLORO-3-NITROPYRIDINE
• 2-Bromo-3-fluoro-4-pyridinecarboxylic acid
• 2-Bromo-3-chloro-6-(trifluoromethyl)pyridine
• 2-BROMO-NICOTINONITRILE
• 2-BROMO-3-CHLOROPYRIDINE-4-BORONIC ACID
• Methyl 2-BroMo-3-fluoroisonicotinate
• 2-bromo-3-methoxypyrazine
• 2-Bromo-3-chloro-4-methylpyridine