4-Amino-3-chlorophenol Chemical Properties

Melting point:

159-160℃

Boiling point:

287.3±25.0 °C(Predicted)

Density 

1.406±0.06 g/cm3(Predicted)

RTECS 

SJ5710000

storage temp. 

2-8°C(protect from light)

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Crystalline Powder

pka

9.26±0.18(Predicted)

color 

White

Stability:

Hygroscopic

InChI

InChI=1S/C6H6ClNO/c7-5-3-4(9)1-2-6(5)8/h1-3,9H,8H2

InChIKey

PNLPXABQLXSICH-UHFFFAOYSA-N

SMILES

C1(O)=CC=C(N)C(Cl)=C1

CAS DataBase Reference

17609-80-2(CAS DataBase Reference)

Safety Information

HazardClass 

6.1

HS Code 

2922290090

4-Amino-3-chlorophenol Usage And Synthesis

Chemical Properties

Light yellow solid

Uses

4-Amino-3-Chlorophenol acts as a synthetic reagent for the preparation of Benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer''s disease treatment.

Application

The 4-amino-3-chlorophenol is a crucial intermediate for preparing a tyrosine kinase inhibitor, tivozanib, and a late liver cancer drug, lenvatinib. As a crucial pharmaceutical chemical intermediate, 4-amino-3-chlorophenol is widely applied to the design and synthesis of medicaments for resisting tumors, cardiovascular diseases, neurological diseases, and the like.

Synthesis

Starting from o-chloronitrobenzene with introducing hydroxyl groups in the presence of strong acids and molybdenum salts as catalysts could synthesize 4-amino-3-chlorophenol. Besides, using m-chlorophenol as a starting material and introducing hydroxyl on a benzene ring through diazotization and coupling also could synthesize 4-Amino-3-chlorophenol.

4-Amino-3-chlorophenol(17609-80-2)Related Product Information

• 4-Amino-3-chlorophenol hydrochloride,98%,4-AMINO-3-CHLOROPHENOL HCL,4-AMINO-3-CHLOROPHENOL HYDROCHLORIDE
• Tris(hydroxymethyl)aminomethane
• 4-Aminophenol
• 2-Aminophenol
• 4-Chlorophenol
• 6-Aminocaproic acid
• 3-Chlorophenol
• Glycine
• 3-Aminophenol
• ALTRENOGEST
• CHLORTHION
• 1-AMINO-2-CHLORO-4-HYDROXY-9,10-ANTHRACENEDIONE
• 2,6-DICHLORO-4-(TRIFLUOROMETHOXY)ANILINE
• Lufenuron
• 4-METHOXY-2-CHLOROANILINE
• 2-Amino-6-chlorophenol-4-sulfonic acid
• 2-Methyl-5-amino-4-chlorophenol
• 5-AMINO-2-CHLOROPHENOL,3-amino-6-chloropheno