2-AMINO-2-(4-METHYLPHENYL)ACETIC ACID Chemical Properties

Melting point:

256-257°

Boiling point:

306.8±30.0 °C(Predicted)

Density 

1.200±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Acetonitrile: Slightly soluble: 0.1-1 mg/ml

form 

solid

pka

2.03±0.10(Predicted)

color 

White

CAS DataBase Reference

13227-01-5(CAS DataBase Reference)

Safety Information

HazardClass 

IRRITANT

HS Code 

2922498590

2-AMINO-2-(4-METHYLPHENYL)ACETIC ACID Usage And Synthesis

Uses

2-Amino-2-(p-tolyl)acetic acid is used for optimizing azide skeleton, and is the intermediate in the synthesis of 1,3, 4-thiadiazole compounds. 1,3,4-thiadiazole compounds exhibit potential anti-cancer activity, and inhibit glutaminase (GLSI)[1][2].

References

[1] Kalie A M, et al. Cytosolic Delivery of Proteins by Bioreversible Esterification. JAmChem. 2017. 139(41):14396–14398.
[2] Finlay MRV, et al. Preparation of 1,3,4-thiadiazole compounds and their use in treating cancer: World Intellectual Property Organization, WO2017093301[P]. 2017-06-08.
[3] JERZY ZOŃ  Roman G  Nikolaus Amrhein. Inhibitors of phenylalanine ammonia-lyase: 1-aminobenzylphosphonic acids substituted in the benzene ring[J]. Phytochemistry, 2002, 59 1: Pages 9-21. DOI: 10.1016/s0031-9422(01)00425-3

2-AMINO-2-(4-METHYLPHENYL)ACETIC ACID(13227-01-5)Related Product Information

• 4-(Trifluoromethyl)-DL-phenylglycine
• (RS)-MCPG
• 2-AMINO-2-(4-METHYLPHENYL)ACETIC ACID
• L-BETA-HOMO(3-METHYLPHENYL)GLYCINE
• L-BETA-HOMO(4-METHYLPHENYL)GLYCINE
• L-BETA-HOMO(2-METHYLPHENYL)GLYCINE
• N-BETA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-L-HOMO(4-METHYLPHENYL)GLYCINE
• N-BETA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-L-HOMO(2-METHYLPHENYL)GLYCINE
• N-BETA-T-BUTOXYCARBONYL-BETA-L-HOMO(2-METHYLPHENYL)GLYCINE
• N-BETA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-L-HOMO(3-METHYLPHENYL)GLYCINE
• N-BETA-T-BUTOXYCARBONYL-BETA-L-HOMO(4-METHYLPHENYL)GLYCINE
• (R)-4-CARBOXYPHENYLGLYCINE
• (RS)-4-CARBOXYPHENYLGLYCINE
• (S)-4-CARBOXYPHENYLGLYCINE
• AIDA
• AMINO(4-ISOPROPYLPHENYL)ACETIC ACID
• E4CPG
• (S)-4-CARBOXY-3-HYDROXYPHENYLGLYCINE