Bis(NHS)PEG5 Chemical Properties

Boiling point:

632.5±65.0 °C(Predicted)

Density 

1.37±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO, DCM, DMF

form 

solid or viscous liquid

color 

Colorless to Almost colorless

Water Solubility 

water: soluble

InChI

1S/C22H32N2O13/c25-17-1-2-18(26)23(17)36-21(29)5-7-31-9-11-33-13-15-35-16-14-34-12-10-32-8-6-22(30)37-24-19(27)3-4-20(24)28/h1-16H2

InChIKey

FTYUGLBWKRXQBD-UHFFFAOYSA-N

SMILES

O=C(CCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)ON2C(CCC2=O)=O

CAS DataBase Reference

756526-03-1

Safety Information

WGK Germany 

WGK 3

HS Code 

2928.00.5000

Storage Class

10 - Combustible liquids

Bis(NHS)PEG5 Usage And Synthesis

Description

Bis-PEG5-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Uses

Bis(NHS)PEG5 is used in targeting M2-like tumor-associated macrophages by using melittin-based pro-apoptotic peptide conjugates with anti-cancer drugs,

General Description

By contrast to typical PEG reagents that contain heterogeneous mixtures of different PEG chain lengths, this PEG reagent is a homogeneous compound of defined molecular weight and spacer arm length, providing greater precision in optimization and characterization of crosslinking applications. Homobifunctional crosslinkers containing N-hydroxysuccinimide (NHS) esters are often used for low-resolution 3-D studies of protein structure and protein interaction analysis.

reaction suitability

reagent type: cross-linking reagent
reactivity: amine reactive

IC 50

Cleavable Linker; PEGs; Alkyl/ether

Bis(NHS)PEG5(756526-03-1)Related Product Information

• BOC-MET-OSU
• alpha, oMega-DisucciniMidyl diethylene glycol
• Bis(2,5-dioxopyrrolidin-1-yl) (disulfanediylbis(ethane-2,1-diyl)) dicarbonate
• N-Mal-N-bis(PEG4-NHS ester)
• alpha, oMega-DisucciniMidyl hexaethylene glycol
• Bis-Propargyl-PEG9
• Bis-Propargyl-PEG4
• alpha, oMega-Dipropionic acid triethylene glycol
• Bis-propargyl-PEG6
• Diethylene Glycol Bis(2-propynyl) Ether
• 4,7,10,13,16-Pentaoxanonadeca-1,18-diyne
• MPEG3-NHS
• 1-AMinooctaethylene Glycol
• FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID
• Bis-peg13-nhs ester
• Bis-PEG12-NHS ester
• alpha, oMega-DisucciniMidyl triethylene glycol
• Bis-peg10-nhs ester