Basic information Safety Supplier Related

GSK2838232

Basic information Safety Supplier Related

GSK2838232 Basic information

Product Name:
GSK2838232
Synonyms:
  • GSK2838232
  • (3beta)-3-(3-Carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(3-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-28-norlup-18-en-21-one
  • GSK-2838232A; GSK 2838232A
  • CS-947
  • GSK2838232(GSK2838232A)
  • HIV Inhibitor GS2838232
  • 28-Norlup-18-en-21-one, 3-(3-carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(3-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-, (3β)-
  • EX-A202
CAS:
1443461-21-9
MF:
C48H73ClN2O6
MW:
809.56
Mol File:
1443461-21-9.mol
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GSK2838232 Chemical Properties

Boiling point:
817.1±65.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
4.48±0.28(Predicted)
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GSK2838232 Usage And Synthesis

Biological Activity

gsk2838232 is an hiv-1 maturation inhibitor [1] [2].hiv-1 maturation inhibitors disrupt the cleavage of the hiv-1 gag protein immediate precursor by the enzyme hiv-1 protease. maturation inhibitors bind the gag protein, which leads to the formation of immature, noninfectious virus particles incapable of infecting other cells. also, maturation inhibitors inhibit hiv infections with resistance.gsk2838232 is a hiv-1 maturation inhibitor and is active against a broad range of isolates, including those resistant to bevirimat [1]. gsk2838232 was developed for the treatment of chronic hiv infection. a phase i study in hiv-negative individuals had been completed. single doses of 5, 10 or 20 mg gsk2838232 were used to evaluate the initial safety, tolerability, pharmacokinetics profile, and the effects of food and ritonavir on gsk2838232’s bioavailability and pharmacokinetics [2].

References

[1]. olender sa, taylor bs, wong m, et al. croi 2015: advances in antiretroviral therapy. croi 2015 highlights: antiretroviral therapy volume 23 issue 1 march/april 2015.
[2]. horn t, collins s. the antiretroviral pipeline. antiretrovirals, 2014 pipeline report.

GSK2838232Supplier

Shanghai Boyle Chemical Co., Ltd.
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HangZhou YuHao Chemical Technology Co., Ltd.
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Shanghai Lollane Biological Technology Co.,Ltd.
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