P-5091
P-5091 Basic information
- Product Name:
- P-5091
- Synonyms:
-
- 1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone
- P5091, >=98%
- CS-726
- P5091; P-005091; P 005091; P 5091; P-5091
- 1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone
- Ethanone, 1-[5-[(2,3-dichlorophenyl)thio]-4-nitro-2-thienyl]-
- 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]-ethanone P005091
- P005091(P5091)
- CAS:
- 882257-11-6
- MF:
- C12H7Cl2NO3S2
- MW:
- 348.22
- Product Categories:
-
- Inhibitors
- Mol File:
- 882257-11-6.mol
P-5091 Chemical Properties
- Boiling point:
- 452.4±45.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- color
- light yellow to dark yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
P-5091 Usage And Synthesis
Description
P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM).1,2 Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.1?P5091 displays antiangiogenic activity in vivo.2?Cell permeable
Uses
P005091 is a selective dual inhibitor of the cancer-related deubiquitylating proteases USP7 and USP47.
Uses
P5091 has been used:
- as a ubiquitin specific peptidase 47 (USP47) inhibitor in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cellular viability of MCF-10A cells
- as a USP7 inhibitor to study the regulatory role for USP7 on inflammasome activation
- as USP7 inhibitor in drug susceptibility assays to study its effect on bone marrow?resident tumor cells (BMRTCs)/ circulating tumor cells (CTCs)
Biochem/physiol Actions
P5091 plays an important role in ovarian cancer, as it can prevent the growth of cells and can promote necrosis and apoptosis.
in vivo
In animal tumor model studies, P005091 is well tolerated, inhibits tumor growth, and prolongs survival. Combining P005091 with lenalidomide, HDAC inhibitor SAHA, or dexamethasone triggers synergistic anti-MM activity[1].
References
[1] DHARMINDER CHAUHAN. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.[J]. Cancer Cell, 2012, 22 3: 345-358. DOI:10.1016/j.ccr.2012.08.007
[2] JOSEPH WEINSTOCK. Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47[J]. ACS Medicinal Chemistry Letters, 2012, 3 10: 789-792. DOI:10.1021/ml200276j
P-5091Supplier
- Tel
- sales@boylechem.com
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 0531-88811783
- sales@trio-pharmatech.com
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- 0411-62910999 13889544652
- sales@meilune.com
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- 021-58950125
- info@chemexpress.com