CNX-1351
CNX-1351 Basic information
- Product Name:
- CNX-1351
- Synonyms:
-
- 1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione CNX1351
- CNX-1351, >=98%
- CNX-1351
- 1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione
- 1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione
- CS-1069
- CNX-1351; CNX 1351; CNX1351
- CNX1351cas
- CAS:
- 1276105-89-5
- MF:
- C30H35N7O3S
- MW:
- 573.71
- Product Categories:
-
- Inhibitors
- Mol File:
- 1276105-89-5.mol
More
Less
CNX-1351 Chemical Properties
- Density
- 1.328±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 33.33 mg/mL (58.10 mM; Need ultrasonic)
- form
- Powder
- pka
- 12.22±0.40(Predicted)
More
Less
CNX-1351 Usage And Synthesis
Biological Activity
CNX-1351 is a potent and selective PI3Kα inhibitor with IC50 of 6.8 nM.
in vivo
CNX-1351 inhibits p-Akt Ser473 in mouse spleens and bonds to PI3Kα in vivo. It is delivered into the intraperitoneal cavity of nude mice at 100 mg/kg once a day for 5 consecutive days (n=3 mice per group).
target
| PI3Kα 6.8 nM (IC 50 ) | PI3Kβ 166 nM (IC 50 ) | PI3Kδ 240.3 nM (IC 50 ) | PI3Kγ 3020 nM ( IC 50 ) |
CNX-1351Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
AdooQ BioScience, LLC
- Tel
- +1 (866) 930-6790
- info@adooq.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com