DisodiuM trans-crocetinate
DisodiuM trans-crocetinate Basic information
- Product Name:
- DisodiuM trans-crocetinate
- Synonyms:
-
- DisodiuM trans-crocetinate
- Transcrocetinate sodium
- Transcrocetinate disodium
- Trans Sodium Crocetinate( Disodium trans-crocetinate)
- Transcrocetinate disodium (Synonyms: Disodium trans-crocetinate)
- Transcrocetinate disodium (Disodium trans-crocetinate)
- iGluR,Transcrocetinate disodium,Inhibitor,inhibit,Ionotropic glutamate receptors
- Disodium salt of saffron acid
- CAS:
- 591230-99-8
- MF:
- C20H25NaO4
- MW:
- 352.41
- Mol File:
- 591230-99-8.mol
DisodiuM trans-crocetinate Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- H2O:16.67(Max Conc. mg/mL);44.77(Max Conc. mM)
DisodiuM trans-crocetinate Usage And Synthesis
Biological Activity
DisodiuM trans-crocetinate, extracted from saffron (Crocus sativus L.), is a high-affinity NMDA receptor antagonist.
in vitro
Transcrocetinate (Transcrocetin, trans-Crocetin), a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron. To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 μM) reveal no negative significant changes in cellular viability. Transcrocetinate at 10 μM level does not change viability while higher concentrations (40-160 μM) reduces significantly cellular viability.
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target
NMDA receptor
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DisodiuM trans-crocetinate(591230-99-8)Related Product Information
- Dimethylcrocetin
- 8,8'-DIAPOCAROTENEDIOIC ACID
- trans-Crocetin (β-D-gentiobiosyl) ester
- Crocin
- β-D-Glucopyranose, 1-[hydrogen (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]
- 8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester
- 1,1'-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]-b-D-Glucopyranose
- Picrocrocin
- 1-[(2E,4E,6E,8E,10E,12E,14E)-b-D-glucopyranosyl 2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate] 6-O-b-D-glucopyranosyl-b-D-Glucopyranose