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SR9011

Basic information Biochem/physiol Actions Safety Supplier Related

SR9011 Basic information

Product Name:
SR9011
Synonyms:
  • SR-9011;SR 9011;SR9011
  • CS-2028
  • SR9011
  • SR9001
  • 3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-1-pyrrolidinecarboxamide
  • Stenabolic Sr9011
  • White Powder SR9011Cas# 1379686-29-9 Raw Chemical Material
  • SR-9011;SR 9011
CAS:
1379686-29-9
MF:
C23H31ClN4O3S
MW:
479.04
EINECS:
1379686-290-9
Product Categories:
  • 1379686-29-9
  • SARMS
Mol File:
1379686-29-9.mol
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SR9011 Chemical Properties

Boiling point:
642.8±50.0 °C(Predicted)
Density 
1.254±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.71±0.40(Predicted)
color 
Dark Yellow to Very Dark Brown
InChI
InChI=1S/C23H31ClN4O3S/c1-2-3-4-12-25-23(29)27-13-11-19(16-27)15-26(14-18-5-7-20(24)8-6-18)17-21-9-10-22(32-21)28(30)31/h5-10,19H,2-4,11-17H2,1H3,(H,25,29)
InChIKey
PPUYOYQTTWJTIU-UHFFFAOYSA-N
SMILES
N1(C(NCCCCC)=O)CCC(CN(CC2=CC=C(Cl)C=C2)CC2SC([N+]([O-])=O)=CC=2)C1
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SR9011 Usage And Synthesis

Biochem/physiol Actions

SR9011 is a potent nuclear receptor REV-ERB agonist (EC50 of REV-ERBα- and REV-ERBβ-dependent repressor activity = 790 and 560 nM, respectively, by cell-based reporter assay) that stimulates REV-ERB-dependent target genes suppression both in cultures in vitro and in mice in vivo (100 mg/kg i.p., b.i.d.) without activity toward a panel of 46 other nuclear receptors. SR9011 is shown to modulate circadian behavior by suppressing the transcription factors BMAL1 (brain and muscle ARNT-like protein 1) and CLOCK (circadian locomotor output cycles kaput) as well as induce energy expenditure and weight loss by regulating genes involved in lipid and glucose metabolism in mice in vivo with good bioavailabiilty (plasma conc. = 0.53 and 15.3 μM 2 hr post 10 or 100 mg/kg i.p. dosage; brain conc. = 0.24 μM 2 hr post 10 mg/kg i.p.), while its structure analog GSK4112 shows no plasma exposure.

Uses

SR 9011 is a synthetic REV-ERBα/β agonist with activity in vivo. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock.

Application

SR9011 has been used as a nuclear receptor subfamily 1 group D member 1 (NR1D1) receptor agonist:
to study its effects on microglial immune-metabolism
to study its effects on insulin secretion from human type 2 diabetes islet cells
to study its effects on thyroid-stimulating hormone β (TSHβ) gene expression

Side effects

After a close investigation of the effects of SR9011 on humans, it is deduced that the drug is well tolerated without any significant side effects. However, minor effects on sleep, such as transient insomnia, were reported by some users. Nevertheless, it is always best to stick to the given drug dose if you don’t want to experience any harm.

SR9011Supplier

Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Email
marketing@targetmol.com
PURE SYNMR INGREDIENTS LIMITED
Tel
021-26015538
Email
sven_shi@puresynmr.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Amadis Chemical Company Limited
Tel
571-89925085
Email
sales@amadischem.com