Basic information Safety Supplier Related

Gefitinib-d6

Basic information Safety Supplier Related

Gefitinib-d6 Basic information

Product Name:
Gefitinib-d6
Synonyms:
  • Gefitinib-d6
  • Hexadeuterated gefitinib
  • [2H6]-Gefitinib
  • N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
CAS:
1228664-49-0
MF:
C22H24ClFN4O3
MW:
446.91
Mol File:
1228664-49-0.mol
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Gefitinib-d6 Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.3 mg/ml
form 
A solid
color 
White to off-white
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Gefitinib-d6 Usage And Synthesis

Description

Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib by GC- or LC-MS. Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 μM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 μM). Gefitinib (0.1 to 1 μM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).

Uses

Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.

Gefitinib-d6Supplier

S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Email
3001272453@qq.com
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-66023220 0086-15250997978
Email
1511893459@qq.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Email
sales@chemegen.com