Gefitinib-d6
Gefitinib-d6 Basic information
- Product Name:
- Gefitinib-d6
- Synonyms:
-
- Gefitinib-d6
- Hexadeuterated gefitinib
- [2H6]-Gefitinib
- N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
- CAS:
- 1228664-49-0
- MF:
- C22H24ClFN4O3
- MW:
- 446.91
- Mol File:
- 1228664-49-0.mol
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Gefitinib-d6 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.3 mg/ml
- form
- A solid
- color
- White to off-white
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Gefitinib-d6 Usage And Synthesis
Description
Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib by GC- or LC-MS. Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 μM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 μM). Gefitinib (0.1 to 1 μM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).
Uses
Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.
Gefitinib-d6Supplier
S.Z. PhyStandard Bio-Tech. Co., Ltd.
- Tel
- 0755-4000505016 13380397412
- 3001272453@qq.com
Nanjing XiZe Biotechnology CO., Ltd.
- Tel
- 025-66023220 0086-15250997978
- 1511893459@qq.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shenzhen Polymeri Biochemical Technology Co., Ltd.
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
- Tel
- 18818260767
- sales@chemegen.com
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Gefitinib-d6(1228664-49-0)Related Product Information
- 4-(3-Chloropropyl)morpholine
- 4,4'-(propane-1,3-diyl)bismorpholine
- Gefitinib N-Oxide
- 4-Defluoro-4-hydroxy Gefitinib
- Gefitinib
- 3-Hydroxy-4-methoxybenzonitrile
- 3-Chloro-4-fluoroaniline
- 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
- 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
- 2-aMino-4-Methoxy-5-(3-Morpholinopropoxy)benzaMide
- 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one
- 3,4-Dichloroaniline
- N-(3-chloro-4-fluorophenyl)-7 -methoxy-6-(3-morpholinopropoxy)-N-(3-morpholinopropyl)quinazolin-4-amine
- Gefitinib 3,4-Difluoro Impurity HCl
- 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one
- 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol
- 3-Deschloro-4-Desfluoro-4-Chloro-3-Fluorogefitinib
- 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate