5-chloro-2,3-diphenylpyrazine Chemical Properties

Melting point:

126-128℃ (methanol )

Boiling point:

145°C/0.001mmHg(lit.)

Density 

1?+-.0.06 g/cm3(Predicted)

pka

-2.16±0.10(Predicted)

form 

powder to crystal

color 

White to Orange to Green

InChI

InChI=1S/C16H11ClN2/c17-14-11-18-15(12-7-3-1-4-8-12)16(19-14)13-9-5-2-6-10-13/h1-11H

InChIKey

VUGNCPVAXWZTOL-UHFFFAOYSA-N

SMILES

C1(C2=CC=CC=C2)=NC=C(Cl)N=C1C1=CC=CC=C1

CAS DataBase Reference

41270-66-0

Safety Information

HS Code 

2933.99.5300

5-chloro-2,3-diphenylpyrazine Usage And Synthesis

Uses

2-Chloro-5,6-diphenylpyrazine is a diphenylpyrazine derivative used in a study to determine a novel class of prostacyclin receptor agonists.

Synthesis

50 gm of 2-hydroxy-5,6-diphenylpyrazine obtained was treated with 250 ml of POCI3 and then heated the reaction mixture at 100-110 °C with stirring for 5-6 hrs. The reaction mixture was cooled to room temperature and poured in 1000 ml of ice water at 0-5 °C and maintained with stirring for 60 minutes. The solid obtained was filtered, washed with water and dried to obtain 41.3 gm of 5-chloro-2,3-diphenylpyrazine. Yield: 77.00 percent.

5-chloro-2,3-diphenylpyrazine(41270-66-0)Related Product Information

• Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)oxy]butoxy]-
• 2-Pyrazinamine, N-(1-methylethyl)-5,6-diphenyl-
• 5,6-DIPHENYLPYRAZIN-2-OL
• N-(methylsulfonyl)glycine
• 2,3-Dichloro-5,6-diphenylpyrazine
• 1-Butanol, 4-[(5,6-diphenyl-2-pyrazinyl)oxy]-
• 2,3-DIPHENYLPYRAZINE
• Bromoacetic acid
• 2-T-BUTYL GLYCOLATE
• 4-(Isopropylamino)butanol
• Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)oxy]butoxy]-, 1,1-dimethylethyl ester
• ( 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butylester )
• SELEXIPAG interMediate
• [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID
• Acetamide, 2-[4-[(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)-
• Acetamide, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-