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Benzocaine hydrochloride

Basic information Description References Safety Supplier Related

Benzocaine hydrochloride Basic information

Product Name:
Benzocaine hydrochloride
Synonyms:
  • Benzocaine hydrochl
  • Benzoic acid, 4-aMino-,ethyl ester, hydrochloride (1:1)
  • ETHYL 4-AMINOBENZOATE HYDROCHLORIDE
  • BENZOCAINE HCL
  • BENZOCAINE HYDROCHLORIDE
  • Benzocaine hydrochloride(Cas number23239-88-5)
  • Ethyl p-aminobenzoate hydrochloride
  • benzocaina benzocane powder
CAS:
23239-88-5
MF:
C9H11NO2.ClH
MW:
201.65
EINECS:
205-634-3
Mol File:
23239-88-5.mol
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Benzocaine hydrochloride Chemical Properties

Melting point:
291-292 °C
Boiling point:
118-119 °C(Press: 0.8 Torr)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
Water Solubility 
Water: Insoluble
Stability:
Hygroscopic
InChI
InChI=1S/C9H11NO2.ClH/c1-2-12-9(11)7-3-5-8(10)6-4-7;/h3-6H,2,10H2,1H3;1H
InChIKey
JAADDQHUJDUAKW-UHFFFAOYSA-N
SMILES
C1(C=CC(N)=CC=1)C(=O)OCC.Cl
CAS DataBase Reference
23239-88-5(CAS DataBase Reference)
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Benzocaine hydrochloride Usage And Synthesis

Description

Benzocaine is a local anesthetic drug. It is directly applied to the skin and used as a topical pain reliever or in cough drops. Benzocaine works by creating a chemical barrier that halts the build up of sodium, which accumulates as the nerve endings are stimulated by pain. When sodium builds up, electrical signals also build in the nerve ending and are transmitted to the brain, which interprets the signals as pain. Benzocaine hydrochloride is a salt modification of benzocaine, formed when benzocaine is complexed with hydrochloric acid. Compared to benzocaine, benzocaine hydrochloride is more water soluble, making it more appropriate for oral administration.
Benzocaine hydrochloride is usually made into powder or oil paste and used to heal wounds, ulcers, burns, skin abrasion, and hemorrhoids. Through the reduction in the excretion of ammonia and carbon dioxide of fish by benzocaine hydrochloride, the pH and alkalinity values of the transport water remains constant, thereby, benzocaine hydrochloride is used as an aid in the transport of fish.

References

[1] J.T. Ferreira, H.J. Schoonbee, G. L. Smit (1984) The use of benzocaine-hydrochloride as an aid in the transport of fish, Aquaculture, 42, 169-174
[2] https://en.wikipedia.org/wiki/Benzocaine

Uses

Benzocaine Hydrochloride can be used as promising MAO inhibitors.

Application

Benzocaine hydrochloride is an antimicrobial agent that belongs to the group of quaternary ammonium compounds. It is a local anesthetic and topical antiseptic that is used in topical formulations for the treatment of infectious diseases. It is active against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis. It has been shown to have no adverse effects on blood groups and has been found to be safe in toxicity studies. This compound has been shown to have a direct effect on Na channels and may also inhibit the growth of bacterial cells by affecting their cell membranes. It can be obtained in crystalline form or as an amorphous solid, which may affect its rate of dissolution and therefore its clinical relevance.

Mode of action

Benzocaine Hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.

Benzocaine hydrochlorideSupplier

Hebei Clavier Biotechnology Co., LTD Gold
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Hebei Guanlang Biotechnology Co., Ltd. Gold
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13383116422
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Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.
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0519-85195575 15861192208
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070 13913916777;
Email
info@chemlin.com.cn