5-epi EMtricitabine Chemical Properties

Melting point:

>166°C (dec.)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Pale Beige

Stability:

Hygroscopic

InChI

InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6-/m1/s1

InChIKey

XQSPYNMVSIKCOC-PHDIDXHHSA-N

SMILES

C1(=O)N([C@@H]2O[C@@H](CO)SC2)C=C(F)C(N)=N1

5-epi EMtricitabine Usage And Synthesis

Uses

5-epi Emtricitabine is an epimer of Emtricitabine (E525000), a nucleoside reverse transcriptase inhibitor approved for treatment of human immunodeficiency virus (HIV) 1, and also has antagonistic activity against the hepatitis B virus. 5-epi Emtricitabine is also used as a reagent for the synthesis of β-L-(2R,5S)- and α-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential HIV agents.

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