2-Hydroxy Atorvastatin Calcium Salt Chemical Properties

Melting point:

>166°C (dec.)

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Yellow

Stability:

Hygroscopic

2-Hydroxy Atorvastatin Calcium Salt Usage And Synthesis

Chemical Properties

White to Pale Yellow Solid

Uses

di(2-Hydroxy Atorvastatin) Calcium Salt is a metabolite of Atorvastatin Calcium Salt (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Biological Activity

2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM. It inhibits lipid hydroperoxide formation and copper sulfate-induced thiobarbituric acid reactive substances (TBARS) formation in 1,2-dilinoleoyl-sn-glycero-3-PC (DLPC) vesicles and human LDL, respectively, in a concentration-dependent manner. 2-Hydroxy Atorvastatin reduces cell death induced by oxygen-glucose deprivation (OGD) in primary rat cortical neurons and increases phosphorylation of cAMP-response-element-binding protein (CREB) in GABAergic neurons when used at a concentration of 600 nM following OGD.

2-Hydroxy Atorvastatin Calcium Salt(265989-46-6)Related Product Information

• Dihydroxy Diketo Atorvastatin IMpurity
• 3-Oxo Atorvastatin tert-Butyl Ester
• Atorvastatin Impurity 31
• Atorvastatin Impurity 15
• 2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide
• 2,3-Dehydroxy Atorvastatin Sodium Salt
• Atorvastatin Impurity 20
• Atorvastatin IMpurity G
• Ortho-Hydroxy atorvastatin calcium salt
• O-HYDROXY ATORVASTATIN LACTONE
• ATV-FX1 sodiuM salt
• 5-Oxo Atorvastatin tert-Butyl Ester
• Atorvastatin Impurity 46
• Atorvastatin Impurity 38
• Atorvastatin
• Difluoro Atorvastatin Acetonide tert-Butyl Ester
• Atorvastatin Dehydro Lactone
• 3S,5R isoMer, or (3S,5R)-7-[3-(phenylcarbaMoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calciuM salt