ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > KRCA-0008
KRCA-0008
KRCA-0008 Basic information
- Product Name:
- KRCA-0008
- Synonyms:
-
- CS-1715
- KRCA-0008
- KRCA-008
- 1,1'-[(5-Chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bisethanone
- Ethanone, 1,1'-[(5-chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bis-
- KRCA-0008 >=98% (HPLC)
- GABA NG
- GABANG
- CAS:
- 1472795-20-2
- MF:
- C30H37ClN8O4
- MW:
- 609.12
- Product Categories:
-
- Inhibitors
- Mol File:
- 1472795-20-2.mol
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KRCA-0008 Chemical Properties
- Boiling point:
- 870.2±75.0 °C(Predicted)
- Density
- 1.332±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
- pka
- 3.99±0.50(Predicted)
- color
- White to gray
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KRCA-0008 Usage And Synthesis
Uses
KRCA 0008 is a potent and selective ALK inhibitors for anticancer treatment.
in vivo
KRCA-0008 (25 and 50 mg/kg; p.o. twice a day for two weeks) suppresses tumor growth in an ALK-positive Karpas-299 xenograft model[2].
| Animal Model: | NOD/SCID mice with Karpas-299 xenografts[2] |
| Dosage: | 25 and 50 mg/kg |
| Administration: | Oral gavage; 25 and 50 mg/kg twice a day; for two weeks |
| Result: | Significantly inhibited tumor growth by inhibiting NPM-ALK phosphorylation without showing overt signs of toxicity or significant compound-related body weight loss. |
storage
Store at -20°C
KRCA-0008Supplier
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070 13913916777;
- info@chemlin.com.cn
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
LETOPHARM LIMITED
- Tel
- +86-21-5821 5861
- sales@letopharm.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
SPIRO PHARMA
- Tel
- eric_feng1954@126.com