(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Chemical Properties

storage temp. 

-20°C

solubility 

H2O: soluble20mg/mL, clear

form 

powder

color 

light yellow to dark yellow

Water Solubility 

Soluble to 100 mM in water

Safety Information

WGK Germany 

3

(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Usage And Synthesis

Uses

CORM-3 (carbon monoxide (CO) releasing molecule-3) has been used to study its effect on NLRP3 (leucine-rich-repeat-containing receptor, pyrin-domain-containing 3) inflammasome activation via glycolysis in macrophages and also on hyperglycemia-induced IL-1β (interleukin-1 β) production. It has also been used to study its protective function against H₂O₂-induced apoptosis using primary rabbit lens epithelial cells.

Biochem/physiol Actions

CORM-3 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, has recently been found to be an important gaseous signaling mediator in mammalian cells CORM-3 has been shown to have anti-inflammatory and cardioprotective activity.

storage

Store at -20°C