FMS Chemical Properties

Density 

1.77±0.1 g/cm3(Predicted)

storage temp. 

-20°C

pka

-4.49±0.18(Predicted)

form 

buffered aqueous solution

biological source

rabbit

Specific Activity

18-24nmol/min·mg

FMS Usage And Synthesis

Uses

FMS is a fluorescent reagent with high selectivity.

Biological Activity

FMS also called CSF1R colony stimulating factor 1 receptor, and its ligand CSF1 are linked to poor prognosis in patients with solid tumors, and in patients with female reproductive cancers. In breast cancers with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).

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