Biotin-PEG11-Azide Chemical Properties

Melting point:

37-39 °C

storage temp. 

-20°C

solubility 

Soluble in Water, DMSO, DCM, DMF

form 

solid or viscous liquid

color 

White to off-white

InChIKey

WETRQYMCASPBIY-UHFFFAOYSA-N

SMILES

O=C1NC(C2N1)CSC2CCCCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Biotin-PEG11-Azide Usage And Synthesis

Description

Biotin-PEG11-azide is monodisperse PEG biotinylation reagent that can undergo click chemistry with alkyne containing molecule. The hydrophilic PEG spacer increases aqueous solubility of the molecules conjugated with bioti. It also minimize steric hindrance involved with the binding to avidin molecules.

Uses

Biotin-PEG-azide (MW 3400) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; azide, is a moderately good leaving group, can react with alkyne by Cu-catalyzation, which improve the efficiency of biotin binding targets. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

reaction suitability

reaction type: Biotinylations
reagent type: cross-linking reagent

Biotin-PEG11-Azide(956494-20-5)Related Product Information

• Biotin-PEG11-Amine
• Biotin-PEG11-Mal
• Biotin-PEG-OH (MW 3400)