ETRIMFOS Chemical Properties

Melting point:

-3.35℃

Boiling point:

approximate 77℃

Density 

1.195 g/cm3 (20℃)

vapor pressure 

6.5 x 10^-3 Pa (24 °C)

refractive index 

nD20 1.5068

Flash point:

>100 °C

storage temp. 

APPROX 4°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

liquid

Water Solubility 

40 mg l^-1 (23-24 °C)

pka

-0.67±0.32(Predicted)

color 

Colourless

Merck 

13,3923

BRN 

7136389

CAS DataBase Reference

38260-54-7

EPA Substance Registry System

Etrimfos (38260-54-7)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-50/53

Safety Statements 

60-61

RIDADR 

UN3082 9/PG 3

WGK Germany 

3

RTECS 

TF8350000

Hazardous Substances Data

38260-54-7(Hazardous Substances Data)

Toxicity

LD50 in male rats, mice (mg/kg): 1800, 437 orally; LC50 in carp (mg/l): 13.6 (48 hr); 13.3 (96 hr) (Knutti)

ETRIMFOS Usage And Synthesis

Description

Etrimfos is a colorless liquid, mp ?3.35 ?C, vp 6.5 mPa (20 ?C). Solubility in water is 40 mg/L (23–24 ?C). It is miscible with most organic solvents. Log Kow > 3.3. Neat etrimfos is unstable and degrades ca. 40% in 28 d at 50 ?C, but the dilute solutions in nonpolar solvents and its formulations are stable (about 5% loss in 1 y at ca. 20 ?C). It is hydrolyzed in aqueous media; DT₅₀ (25 ?C) at pH 3, 6, and 9 are 0.4, 16, and 14 d, respectively.

Uses

Agricultural insecticide.

Uses

Satisfar is a pesticide sprayed on plants and vegetables as insecticide to fend off pests.

Uses

Etrimfos is used to control chewing insects in top fruit, vines, olives and a number of other crops. It is also used to control stem borers in rice and insect and acarid pests of stored products.

Definition

ChEBI: Etrimfos is an organic thiophosphate.

Hazard

Toxic.

Metabolic pathway

Etrimfos is principally degraded in soil and plants via dearylation of etrimfos itself or by hydrolysis of etrimfos oxon to the pyrimidinol (6-ethoxy-4-hydroxy-2-ethylpyrimidine), further metabolism of which involves de-ethylation to a dihydroxypyrimidine (2-ethyl-4,6-dihydroxypyrimidine). In mammals both hydrolysis and demethylation to desmethyl etrimfos are involved in detoxification. Additionally, the ethyl and ethoxy groups of the pyrimidinol hydrolysis product may be hydroxylated and conjugated. Etrimfos oxon is metabolically highly unstable and is often not detected.

Degradation

Etrimfos is unstable when pure but dilute solutions in non-polar solvents and formulations are stable. Half-lives in water at pH 3,6 and 9 were 0.4, 16 and 14 days, respectively. Etrimfos is stable to light (PM).

Toxicity evaluation

The acute oral LD₅₀ for rats is 1,600–1,800 mg/kg. Inhalation LC50 (1 h) for rats is >200 mg/L air. NOEL (2 yr) for rats is 6 mg/kg diet (0.3 mg/kg/d). ADI is 3 μg/kg b.w. The principal degradation pathway in mammals, plants, and soils is pyrimidinyl ester bond cleavage: the major metabolites are 6-ethoxy-4-hydroxy- 2-ethylpyrimidine and its further transformed products. Degradation in mammals involves demethylation to desmethyl etrimfos. The DT₅₀ in soils at pH 6.8 was 3–10 d.

ETRIMFOS(38260-54-7)Related Product Information

• Picoxystrobin
• Pirimiphos ethyl
• ETRIMFOS ALCOHOL METABOLITE
• 4,6-Dihydroxy-2-methylpyrimidine
• Pyrimidine, 4-methoxy-2-methyl- (6CI,7CI,8CI,9CI)
• ETRIMFOS ALCOHOL METABOLITE
• 4-HYDROXY-2-METHYLPYRIMIDINE
• 4-Hydroxy-6-aminopyrimidine
• 4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI)
• ETRIMFOS