Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  Aromatic ketones >  1(2H)-Phthalazinone

1(2H)-Phthalazinone

Basic information Safety Supplier Related

1(2H)-Phthalazinone Basic information

Product Name:
1(2H)-Phthalazinone
Synonyms:
  • BENZO[D]PYRIDAZIN-1(2H)ONE
  • 2H-Phthalazin-1-one
  • 1(2H)-Phthalazinone, 98+%
  • 1,2-Dihydrophthalazine-1-one
  • Pthalazone
  • 1,2-Dihydro-1-oxophthalazine, Benzo[d]pyridazin-1(2H)-one, Phthalazone
  • 1(2H)-Phthalazinone, 98+% 5GR
  • Benzo[d]pyridazin-1(2H)one 1(2H)-Phthalazinone
CAS:
119-39-1
MF:
C8H6N2O
MW:
146.15
EINECS:
204-319-8
Product Categories:
  • Aldehyde
  • Miscellaneous
Mol File:
119-39-1.mol
More
Less

1(2H)-Phthalazinone Chemical Properties

Melting point:
183-185 °C(lit.)
Boiling point:
337°C(lit.)
Density 
1.2312 (rough estimate)
refractive index 
1.4900 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Crystalline Powder
pka
12.29±0.20(Predicted)
color 
Off-white to pale yellow
BRN 
3654
InChIKey
IJAPPYDYQCXOEF-UHFFFAOYSA-N
CAS DataBase Reference
119-39-1(CAS DataBase Reference)
EPA Substance Registry System
1(2H)-Phthalazinone (119-39-1)
More
Less

Safety Information

Hazard Codes 
Xn
Risk Statements 
22-68-36/37/38
Safety Statements 
22-24/25-36/37/39-26
WGK Germany 
3
RTECS 
TH9185000
HazardClass 
IRRITANT
HS Code 
29339990
Hazardous Substances Data
119-39-1(Hazardous Substances Data)
Toxicity
mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00139,

MSDS

More
Less

1(2H)-Phthalazinone Usage And Synthesis

Chemical Properties

Off-white to pale yellow crystalline powder

Uses

Phthalazone is a remarkable scaffold in drug discovery. Also, functions as an oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase.

Definition

ChEBI: Phthalazin-1(2H)-one is a member of phthalazines.

General Description

Pale yellow crystals. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for 1(2H)-Phthalazinone are not available. 1(2H)-Phthalazinone is probably combustible.

Purification Methods

Phthalazone crystallises from H2O or EtOH and sublimes in vacuo. [Beilstein 24 H 142, 24 24 III/IV 400.]

1(2H)-Phthalazinone Preparation Products And Raw materials

Preparation Products

Raw materials

1(2H)-PhthalazinoneSupplier

NingBo Sialon Chem Co., Ltd. Gold
Tel
0574-28809768 18658497215
Email
sales@newsialon.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Email
market03@meryer.com
INTATRADE GmbH
Tel
+49 3493/605464
Email
sales@intatrade.de
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Email
Sales-CN@TCIchemicals.com