1(2H)-Phthalazinone Chemical Properties

Melting point:

183-185 °C(lit.)

Boiling point:

337°C(lit.)

Density 

1.2312 (rough estimate)

refractive index 

1.4900 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Crystalline Powder

pka

12.29±0.20(Predicted)

color 

Off-white to pale yellow

BRN 

3654

InChIKey

IJAPPYDYQCXOEF-UHFFFAOYSA-N

CAS DataBase Reference

119-39-1(CAS DataBase Reference)

EPA Substance Registry System

1(2H)-Phthalazinone (119-39-1)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-68-36/37/38

Safety Statements 

22-24/25-36/37/39-26

WGK Germany 

3

RTECS 

TH9185000

HazardClass 

IRRITANT

HS Code 

29339990

Hazardous Substances Data

119-39-1(Hazardous Substances Data)

Toxicity

mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00139,

MSDS

• Language:English Provider:Benzo[d]pyridazin-1(2H)one
• Language:English Provider:SigmaAldrich

1(2H)-Phthalazinone Usage And Synthesis

Chemical Properties

Off-white to pale yellow crystalline powder

Uses

Phthalazone is a remarkable scaffold in drug discovery. Also, functions as an oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase.

Definition

ChEBI: Phthalazin-1(2H)-one is a member of phthalazines.

General Description

Pale yellow crystals. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for 1(2H)-Phthalazinone are not available. 1(2H)-Phthalazinone is probably combustible.

Purification Methods

Phthalazone crystallises from H2O or EtOH and sublimes in vacuo. [Beilstein 24 H 142, 24 24 III/IV 400.]

1(2H)-Phthalazinone(119-39-1)Related Product Information

• beta-Tetralone
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• 4-Chloro-1(2H)-phthalazinone, 98%
• (4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETIC ACID
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• 1,2H-PHTHALAZONE
• 4-(4-Chloro-benzyl)-2H-phthalazin-1-one
• 1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepi
• 1(2h)-phthalazinone,hydrazone,monohydrochlorid