ChemicalBook > Product Catalog > Biochemical Engineering > Amino Acids and Derivatives > Tyrosine derivatives > AG 825
AG 825
AG 825 Basic information
- Product Name:
- AG 825
- Synonyms:
-
- TYRPHOSTIN AG 825
- TYRPHOSTIN C15
- AG 825
- 5-[(BENZTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYLIDENECYANOACETAMIDE
- 5-[(BENZOTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYL-IDENECYANOACETAMIDE
- 4-HYDROXY-3-METHOXY-5-(BENZOTHIAZOLYLTHIOMETHYL)BENZYLIDENECYANOACETAMIDE
- 3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano- 2-Propenamide
- Tyrphostin C15, 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide
- CAS:
- 149092-50-2
- MF:
- C19H15N3O3S2
- MW:
- 397.47
- Product Categories:
-
- Protein Kinase
- Mol File:
- 149092-50-2.mol
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AG 825 Chemical Properties
- storage temp.
- −20°C
- solubility
- DMSO: soluble
- form
- Yellow solid
- Sensitive
- Light Sensitive
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Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
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AG 825 Usage And Synthesis
Uses
A selective ErbB2 inhibitor
Uses
AG 825 is a selective ErbB2 (Neu) inhibitor and apoptosis inducer.
Definition
ChEBI: An organic sulfide that consists of 1,3-benzothiazole-2-thiol in which the hydrogen attached to the sulfur atom is replaced by a 5-[(1E)-3-amino-2-cyano-3-oxoprop-1-en-1-yl]-2-hydroxy-3-methoxybenzyl group. It acts as an epidermal growth factor receptor antagonist.
Biological Activity
Selective ErbB2 inhibitor (IC 50 values are 0.15 and 19 mM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.
storage
Store at +4°C
AG 825Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Suzhou Chireach Biomedical Technology Co., Ltd.
- Tel
- 0512-65856968
- sales@chireach.com
VDM Biochemicals
- Tel
- 0330-2528181
- sales@vdmbio.com
Spectrum Chemical Manufacturing Corp.
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- marketing_china@spectrumchemical.com
Synchem OHG
- Tel
- +49 5662 408730
- info@synchem.de
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AG 825(149092-50-2)Related Product Information
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