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AG 825

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AG 825 Basic information

Product Name:
AG 825
Synonyms:
  • TYRPHOSTIN AG 825
  • TYRPHOSTIN C15
  • AG 825
  • 5-[(BENZTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYLIDENECYANOACETAMIDE
  • 5-[(BENZOTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYL-IDENECYANOACETAMIDE
  • 4-HYDROXY-3-METHOXY-5-(BENZOTHIAZOLYLTHIOMETHYL)BENZYLIDENECYANOACETAMIDE
  • 3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano- 2-Propenamide
  • Tyrphostin C15, 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide
CAS:
149092-50-2
MF:
C19H15N3O3S2
MW:
397.47
Product Categories:
  • Protein Kinase
Mol File:
149092-50-2.mol
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AG 825 Chemical Properties

storage temp. 
−20°C
solubility 
DMSO: soluble
form 
Yellow solid
color 
Light yellow to yellow
Sensitive 
Light Sensitive
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3

MSDS

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AG 825 Usage And Synthesis

Uses

A selective ErbB2 inhibitor

Uses

AG 825 is a selective ErbB2 (Neu) inhibitor and apoptosis inducer.

Definition

ChEBI: An organic sulfide that consists of 1,3-benzothiazole-2-thiol in which the hydrogen attached to the sulfur atom is replaced by a 5-[(1E)-3-amino-2-cyano-3-oxoprop-1-en-1-yl]-2-hydroxy-3-methoxybenzyl group. It acts as an epidermal growth factor receptor antagonist.

Biological Activity

Selective ErbB2 inhibitor (IC 50 values are 0.15 and 19 mM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.

in vivo

AG-825 (20 mg/kg, i.p.) decreases peritoneal inflammation in Zymosan (HY-159069)-treated mice, and increases lung neutrophil apoptosis and macrophage efferocytosis in a murine acute lung injury model[4].
AG-825 (1 mg/kg, min-osmotic pump, 14 days) causes cardiac dilation and selective increase in β1AR density in mice[7].

Animal Model:Murine model of LPS induced acute lung inflammation[4]
Dosage:20 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Had no effect on percentage of, or absolute number of neutrophils or macrophages.
Increased the percentage of neutrophil apoptosis.
Elevated macrophage efferocytosis.
Animal Model:Murine model of Zymosan (HY-159069)-induced peritonitis[4]
Dosage:20 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Did not induce leukopenia.
Showed fewer inflammatory cells in peritoneal lavage.
Reduced the neutrophil chemoattractant and proinflammatory cytokine, KC.
Reduced IgM.

IC 50

ErbB2: 0.35 μM (IC50); EGFR: 19 μM (IC50)

storage

Store at +4°C

AG 825Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Suzhou Chireach Biomedical Technology Co., Ltd.
Tel
0512-65856968
Email
sales@chireach.com
VDM Biochemicals
Tel
0330-2528181
Email
sales@vdmbio.com
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Email
marketing_china@spectrumchemical.com
Synchem OHG
Tel
+49 5662 408730
Email
info@synchem.de
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AG 825(149092-50-2)Related Product Information