2-(AMINOMETHYL)-18-CROWN-6 Chemical Properties

Boiling point:

135 °C/0.08 mmHg (lit.)

Density 

1.126 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.479(lit.)

Flash point:

113 °C

pka

9.11±0.29(Predicted)

BRN 

4184588

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

2-(AMINOMETHYL)-18-CROWN-6 Usage And Synthesis

Uses

2-Aminomethyl-18-crown-6 (AM-18-C-6) can be used to prepare:

• AM-18-C-6 bonded Merrifield peptide resin, which is used to study the absorption and the isotopic effect of magnesium.
• Schiff base of gossypol with aminomethyl crown ether for complexation of monovalent cations.
• Crown tagged triarylphosphine by reacting with triphenylphosphine carboxylic acid. These tagged triarylphosphine reagents are used in Mitsunobu and Heck reactions for the removal of phosphine derived by-products.
• 1,16-hexadecanoyl-bis-(2-aminomethyl)-18-crown-6 (bola A-16), which is utilized as a vesicular carrier in a drug delivery system.

2-(AMINOMETHYL)-18-CROWN-6(83585-61-9)Related Product Information

• 15-Crown-5
• 2-(AMINOMETHYL)-18-CROWN-6
• 2-[2-(3-aminopropoxy)ethoxy]ethanol
• 3-(2-ETHOXYETHOXY)PROPYLAMINE
• 18-Crown-6
• 1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL
• 1-(2-METHYL-18-CROWN-6)-3-METHYLIMIDAZOLIUM HEXAFLUOROPHOSPHATE