2-(4-Fluorophenyl)-thiophene Chemical Properties

Melting point:

51.0 to 55.0 °C

Boiling point:

252.3±15.0 °C(Predicted)

Density 

1.200±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

solubility 

soluble in Methanol

form 

powder to crystal

color 

Light orange to Yellow to Green

InChI

InChI=1S/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H

InChIKey

PURJRGMZIKXDMW-UHFFFAOYSA-N

SMILES

C1(C2=CC=C(F)C=C2)SC=CC=1

CAS DataBase Reference

58861-48-6

Safety Information

HS Code 

2934999090

2-(4-Fluorophenyl)-thiophene Usage And Synthesis

Chemical Properties

white solid

Uses

2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus.

Synthesis

4-fluorobenzoic boric acid and 2-bromothiophene, Pd catalyst are added in organic solvent and dissolves, obtain material 3, wherein: 4-fluorine Phenylboric acid molar concentration in organic solvent is 0.5mol/L～2mol/L, and 4-fluorobenzoic boric acid with the mol ratio of 2-bromothiophene is 1:1.0～1:1.5,4-fluorobenzoic boric acid is 1:0.005～1:0.1 with the mol ratio of catalyst；Using material 3 with as material 4 Inorganic base aqueous solution carries out pre-incubation respectively to being 1:1.0～1 according to the mol ratio of 4-fluorobenzoic boric acid Yu alkali after reaction temperature: The mode of 3.0 mixes, and reacts under conditions of 50 ℃～80 ℃, then carries out post processing and obtains 2-(4-fluorophenyl) Thiophene.

2-(4-Fluorophenyl)-thiophene(58861-48-6)Related Product Information

• 3-AMINO-2-CYANO-5-(4-FLUOROPHENYL)THIOPHENE,3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBONITRILE
• METHYL 3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLATE
• DUP-697
• Ethyl 2-amino-4-(4-fluorophenyl)thiophene-3-carboxylate ,98%
• 3-AMINO-2-CYANO-5-(4-FLUOROPHENYL)THIOPHENE,3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBONITRILE
• 3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXAMIDE
• 5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLI&
• 6-(4-FLUOROPHENYL)-3,4-DIHYDROTHIENO[3,2-D]-PYRIMIDIN-4-ONE
• METHYL 5-(4-FLUOROPHENYL)-2-THIOPHENECARBOXYLATE
• 4-CHLORO-6-(4-FLUOROPHENYL)THIENO[3,2-D]PYRIMIDINE
• Methyl 2-[(chloroacetyl)amino]-4-(4-fluorophenyl)-thiophene-3-carboxylate
• 2-Amino-N-(2-fluorophenyl)thiophene-3-carboxamide
• Isopropyl 2-amino-4-(4-fluorophenyl)thiophene-3-carboxylate
• N-(5-amino-2-fluorophenyl)thiophene-2-sulfonamide
• 5-(3-fluorophenyl)thiophene-2-carboxylic acid
• methyl 2-[(cyanoacetyl)amino]-4-(4-fluorophenyl)thiophene-3-carboxylate
• ethyl 2-amino-4-(3-fluorophenyl)thiophene-3-carboxylate
• N-(3-amino-4-fluorophenyl)thiophene-2-carboxamide