Cyclopenthiazide
Cyclopenthiazide Basic information
- Product Name:
- Cyclopenthiazide
- Synonyms:
-
- 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(cyclopentylmethyl)-3,4-dih
- 3-cyclopentylmethylhydrochlorothiazidederiv
- cyclomethiazide
- navidrix
- salimed
- salimid
- su8341
- tsiklometiazid
- CAS:
- 742-20-1
- MF:
- C13H18ClN3O4S2
- MW:
- 379.88
- EINECS:
- 212-012-5
- Product Categories:
-
- Aromatics
- Heterocycles
- Active Pharmaceutical Ingredients
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Mol File:
- 742-20-1.mol
Cyclopenthiazide Chemical Properties
- Melting point:
- 230°
- Boiling point:
- 605.6±65.0 °C(Predicted)
- Density
- 1.3650 (rough estimate)
- refractive index
- 1.6100 (estimate)
- storage temp.
- Refrigerator
- solubility
- Acetonitrile (Slightly), DMSO (Slightly), Methanol (Sparingly)
- form
- Solid
- pka
- 9.00±0.40(Predicted)
- color
- White to Off-White
- Water Solubility
- 50mg/L(room temperature)
- CAS DataBase Reference
- 742-20-1(CAS DataBase Reference)
- EPA Substance Registry System
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide (742-20-1)
Cyclopenthiazide Usage And Synthesis
Uses
Cyclopenthiazide is a thiazide diuretic. Cyclopenthiazide is used in the treatment of oedema caused by conditions such as kidney disease, liver cirrhosis and pre-menstrual syndrome as well as in the treatment of hypertension.
Uses
Antihypertensive;Sodium Chloride Symporter Inhibitor
Definition
ChEBI: 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide is a benzothiadiazine.
World Health Organization (WHO)
Cyclopenthiazide, a thiazide diuretic, was introduced in 1968. It continues to be used mainly in combination drugs.
Clinical Use
Thiazide diuretic:
Hypertension
Heart failure
Oedema
Drug interactions
Potentially hazardous interactions with other drugs
Analgesics: increased risk of nephrotoxicity with
NSAIDs; antagonism of diuretic effect. Anti-arrhythmics: hypokalaemia leads to increased
cardiac toxicity; effects of lidocaine and mexiletine
antagonised.
Antibacterials: avoid administration with
lymecycline.
Antidepressants: increased risk of hypokalaemia
with reboxetine; enhanced hypotensive effect with
MAOIs; increased risk of postural hypotension with
tricyclics.
Antiepileptics: increased risk of hyponatraemia with
carbamazepine.
Antifungals: increased risk of hypokalaemia with
amphotericin.
Antihypertensives: enhanced hypotensive effect;
increased risk of first dose hypotension with postsynaptic alpha-blockers like prazosin; hypokalaemia
increases risk of ventricular arrhythmias with sotalol.
Antipsychotics: hypokalaemia increases risk
of ventricular arrhythmias with amisulpride;
enhanced hypotensive effect with phenothiazines;
hypokalaemia increases risk of ventricular
arrhythmias with pimozide - avoid.
Atomoxetine: hypokalaemia increases risk of
ventricular arrhythmias.
Cardiac glycosides: increased toxicity if hypokalaemia
occurs.
Ciclosporin: increased risk of nephrotoxicity and
possibly hypomagnesaemia.
Cytotoxics: increased risk of ventricular arrhythmias
due to hypokalaemia with arsenic trioxide; increased
risk of nephrotoxicity and ototoxicity with platinum
compounds.
Lithium: excretion reduced, increased toxicity
Metabolism
Cyclopenthiazide appears to be entirely excreted unchanged in the urine.
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