2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol Chemical Properties

Boiling point:

114-116 °C (1 mmHg)

Density 

0.91

refractive index 

1.4865-1.4885

storage temp. 

-20°C

pka

14.72±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

Odor

at 10.00 % in dipropylene glycol. woody sandalwood greasy oily waxy

Odor Type

woody

Water Solubility 

INSOLUBLE

LogP

4.300

CAS DataBase Reference

28219-61-6(CAS DataBase Reference)

EPA Substance Registry System

2-Buten-1-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)- (28219-61-6)

Safety Information

Safety Statements 

24/25

MSDS

• Language:English Provider:2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol
• Language:English Provider:ACROS

2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol Usage And Synthesis

Chemical Properties

clear colorless to pale yellowish liquid

Chemical Properties

2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol is amixture of the (E)- and (Z)-isomers. It is a pale yellow liquid with a powerful sandalwood odor and a slight rose nuance. The mixture can be prepared starting from α-campholenaldehyde and butanal. The intermediate unsaturated aldehyde is partially hydrogenated to give the title alcohol.
It is used in perfume compositions for cosmetics, soaps, and detergents.

Uses

Sandacanol is a specific agonist of olfactory receptor (OR10H1). Sandacanol induces cell cycle arrest and some apoptosis in bladder cancer cells[1].

Trade name

Bacdanol® (IFF), Sandacanol (Hangzhou), Sanderol (DRT), Sandranol® (Symrise), Sanjinol (IFF).

References

[1] Lea Weber, et al. Characterization of the Olfactory Receptor OR10H1 in Human Urinary Bladder Cancer. Front Physiol. 2018 May 16;9:456. DOI:10.3389/fphys.2018.00456

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