Hydroxypioglitazone Chemical Properties

Melting point:

157-1580C

Boiling point:

627.6±55.0 °C(Predicted)

Density 

1.325±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer, Under Inert Atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly, Sonicated)

pka

6.35±0.50(Predicted)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

CAS DataBase Reference

146062-44-4

Hydroxypioglitazone Usage And Synthesis

Description

Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (K_i = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC₅₀ = 2.1 μM).

Chemical Properties

Off-White Solid

Uses

A metabolite of Pioglitazone (P471000).

Definition

ChEBI: Hydroxypioglitazone is a member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone. It has a role as a human xenobiotic metabolite. It is a member of thiazolidinediones, a member of pyridines and an aromatic ether. It is functionally related to a pioglitazone.

Hydroxypioglitazone(146062-44-4)Related Product Information

• Pioglitazone
• 4'-Hydroxyacetophenone
• Pioglitazone
• Troglitazone
• Gliquidone
• Pioglitazone hydrochloride
• a-[(Aminocarbonyl)thio]-4-[2-(5-ethyl-2-pyridinyl)ethoxy]benzenepropanoic Acid Ethyl Ester
• Pioglitazone Aldehyde Impurity
• 5-(4-Fluorobenzyl)-2,4-thiazolidinedione
• 4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyaldehyde
• Hydroxy Pioglitazone (M-II) (Mixture of Diastereomers)
• Pioglitazone Sulfonic Acid IMpurity
• 2-[2-(4-BroMophenoxy)ethyl]-5-ethylpyridine
• Pioglitazone Impurity
• 5-{4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl}-2-imino-4-thiazolidinone
• Pioglitazone N-Oxide
• 5-(4-Hydroxybenzyl)-2,4-thiazolidinedione
• 5-[[4-[2-(5-ACETYL-2-PYRIDINYL)ETHOXY]PHENYL]METHYL]-2,4THIAZOLIDINEDIONE