Peucedanocoumarin III
Peucedanocoumarin III Basic information
- Product Name:
- Peucedanocoumarin III
- Synonyms:
-
- Peucedanocoumarin III
- (2E)-2-Methyl-2-butenoic acid (9S,10R)-9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-10-yl ester
- 2-Butenoic acid, 2-methyl-, (9S,10R)-9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-10-yl ester, (2E)-
- CAS:
- 130464-57-2
- MF:
- C21H22O7
- MW:
- 386.4
- Mol File:
- 130464-57-2.mol
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Peucedanocoumarin III Chemical Properties
- Boiling point:
- 486.8±45.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
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Peucedanocoumarin III Usage And Synthesis
Description
Peucedanocoumarin Ⅲ can induce rice resistance to blast disease.
Uses
Peucedanocoumarin III is an inhibitor of (alpha)-synuclein and Huntington protein aggregates that enhances the clearance of nuclear and cytoplasmic β23 aggregates and prevents cytotoxicity induced by disease-associated proteins (i.e., mutant Huntington proteins and α-synuclein). Peucedanocoumarin III may be used in Parkinson's disease research[1].
IC 50
α-synuclein Aggregation
References
[1] Sangwoo Ham, et al. Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates. Mol Cells. 2019 Jun 30;42(6):480-494. DOI:10.14348/molcells.2019.0091
Peucedanocoumarin IIISupplier
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