(S)-Gossypol (acetic acid) Chemical Properties

storage temp. 

Store at -20°C, protect from light, stored under nitrogen

solubility 

DMSO: 50 mg/mL (86.41 mM); Water: < 0.1 mg/mL (insoluble)

form 

Solid

color 

Light yellow to yellow

(S)-Gossypol (acetic acid) Usage And Synthesis

Uses

(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.

IC 50

Bcl-2; Bcl-xL

References

[1] Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63. DOI:10.1158/1078-0432.CCR-04-0551

(S)-Gossypol (acetic acid)(1189561-66-7)Related Product Information

• Gossypol-acetic acid
• GOSSYPOL
• AT-101