Basic information Safety Supplier Related

Benzyl-PEG3-Mes

Basic information Safety Supplier Related

Benzyl-PEG3-Mes Basic information

Product Name:
Benzyl-PEG3-Mes
Synonyms:
  • Benzyl-PEG2-Mes
  • Benzyl-PEG2-MS
  • Benzyl-PEG3-Mes
  • CAS_150272-33-6
  • di(ethylene glycol)monobenzyl ether methanesulfonate
  • Ethanol, 2-[2-(phenylmethoxy)ethoxy]-, 1-methanesulfonate
  • 2-(2-Phenylmethoxyethoxy)ethyl methanesulfonate
  • Ethanol, 2-[2-(phenylmethoxy)ethoxy]-, methanesulfonate
CAS:
150272-33-6
MF:
C12H18O5S
MW:
274.33
Mol File:
150272-33-6.mol
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Benzyl-PEG3-Mes Usage And Synthesis

Biological Activity

Benzyl-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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