Propargyl-PEG3-NHS ester CAS#: 1428629-71-3

Propargyl-PEG3-NHS ester Basic information

Product Name:

Propargyl-PEG3-NHS ester

Synonyms:

Propargyl-PEG3-NHS ester
Alkyne-PEG3-NHS
Propargyl-PEG2-CH2CH2COONHS
Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate
Propargyl-PEG2-Osu
Propargyl-PEG2-CH2CH2COONHS/Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
Propargyl-PEG2-C2-CONHS ester

CAS:

1428629-71-3

MF:

C14H19NO7

MW:

313.3

Product Categories:

peg

Mol File:

1428629-71-3.mol

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Propargyl-PEG3-NHS ester Chemical Properties

Boiling point:: 427.2±55.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF
form: Liquid
color: Colorless to light yellow
InChI: InChI=1S/C14H19NO7/c1-2-6-19-8-10-21-11-9-20-7-5-14(18)22-15-12(16)3-4-13(15)17/h1H,3-11H2
InChIKey: YDRPXORAOIYIGV-UHFFFAOYSA-N
SMILES: C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCC#C

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Safety Information

HS Code: 2942000090

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Propargyl-PEG3-NHS ester Usage And Synthesis

Description

Propargyl-PEG3-NHS ester is a Click Chemistry reagent with a propargyl group and an NHS ester group. The propargyl group can react with biomolecules containing azide group via copper catalyzed Click Chemistry reaction. The NHS ester is an amine reactive group which can be used for derivatizing peptides, antibodies, amine coated surfaces etc.

Biological Activity

Propargyl-PEG3-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Alkyl/ether

Propargyl-PEG3-NHS esterSupplier

Chengdu Pukang Biotechnology Co., Ltd

Tel: 028-82550498 19102685862
Email: sales@pu-kang.com

T&W GROUP

Tel: 021-61551611 13296011611
Email: contact@trustwe.com

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Email: product02@bidepharm.com

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883 15367835770
Email: viola@huatengsci.com

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb6@aikonchem.com

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