Basic information Safety Supplier Related

Propargyl-PEG3-NHS ester

Basic information Safety Supplier Related

Propargyl-PEG3-NHS ester Basic information

Product Name:
Propargyl-PEG3-NHS ester
Synonyms:
  • Propargyl-PEG3-NHS ester
  • Alkyne-PEG3-NHS
  • Propargyl-PEG2-CH2CH2COONHS
  • Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
  • 2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate
  • Propargyl-PEG2-Osu
  • Propargyl-PEG2-CH2CH2COONHS/Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
  • Propargyl-PEG2-C2-CONHS ester
CAS:
1428629-71-3
MF:
C14H19NO7
MW:
313.3
Product Categories:
  • peg
Mol File:
1428629-71-3.mol
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Propargyl-PEG3-NHS ester Chemical Properties

Boiling point:
427.2±55.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
solubility 
Soluble in DMSO, DCM, DMF
form 
Liquid
InChI
InChI=1S/C14H19NO7/c1-2-6-19-8-10-21-11-9-20-7-5-14(18)22-15-12(16)3-4-13(15)17/h1H,3-11H2
InChIKey
YDRPXORAOIYIGV-UHFFFAOYSA-N
SMILES
C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCC#C
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Safety Information

HS Code 
2942000090
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Propargyl-PEG3-NHS ester Usage And Synthesis

Description

Propargyl-PEG3-NHS ester is a Click Chemistry reagent with a propargyl group and an NHS ester group. The propargyl group can react with biomolecules containing azide group via copper catalyzed Click Chemistry reaction. The NHS ester is an amine reactive group which can be used for derivatizing peptides, antibodies, amine coated surfaces etc.

Biological Activity

Propargyl-PEG3-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Alkyl/ether

Propargyl-PEG3-NHS esterSupplier

Chengdu Pukang Biotechnology Co., Ltd
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028-82550498 19102685862
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sales@pu-kang.com
T&W GROUP
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021-61551611 13296011611
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contact@trustwe.com
Bide Pharmatech Ltd.
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400-1647117 15221909166
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product02@bidepharm.com
Hunan HuaTeng Pharmaceutical Co., Ltd.,
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400-8592883 15367835770
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viola@huatengsci.com
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
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Propargyl-PEG3-NHS ester(1428629-71-3)Related Product Information