Ald-Ph-PEG3-Azide Chemical Properties

solubility 

Soluble in DMSO, DCM, DMF

form 

Oil

color 

Colorless to light yellow

Ald-Ph-PEG3-Azide Usage And Synthesis

Description

Ald-Ph-PEG3-azide is a PEG reagent containing a benzaldehyde group and a terminal azide group. The benzaldehyde can react with primary amines. The azide can react with alkynes, DBCO and BCN moieties via Click Chemistry reactions.

Uses

Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Ald-Ph-amido-C2-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Ald-Ph-PEG3-Azide(1807540-88-0)Related Product Information

• Ald--Ph-PEG3-amine
• Ald-Ph-PEG4-t-butyl ester
• Acid-PEG4-t-butyl ester
• Ald--Ph-PEG2-acid
• Ald-Ph-PEG4-acid
• Ald-Ph-PEG2-t-butyl ester
• Ald-PEG4-t-butyl ester
• Acid-PEG3-t-butyl ester
• Acid-PEG6-t-butyl ester
• Ald-PEG5-t-butyl ester
• Acid-PEG5-t-butyl ester
• Ald-Ph-PEG2-amine
• m-PEG4-benzaldehyde
• Ald--Ph-PEG2-NHS
• Ald-PEG4-NHS ester
• Ald-Ph-PEG6-t-butyl ester
• m-PEG4-CH2-aldehyde
• Ald-PEG5-Azide