Propargyl-PEG9-alcohol Chemical Properties

Boiling point:

483.5±40.0 °C(Predicted)

Density 

1.091±0.06 g/cm3(Predicted)

storage temp. 

Store at Room Tem.

pka

14.36±0.10(Predicted)

Propargyl-PEG9-alcohol Usage And Synthesis

Description

Propargyl-PEG9-alcohol is a crosslinker that can participate in copper catalyzed azide-alkyne Click Chemistry reactions to form stable triazole linkage. The PEG spacer increases the hydrophilicity of the molecule in aqueous media.

Uses

Propargyl-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG8-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Goswami LN, et al. Efficient synthesis of diverse heterobifunctionalized clickable oligo(ethylene glycol) linkers: potential applications in bioconjugation and targeted drug delivery. Org Biomol Chem. 2013 Feb 21;11(7):1116-26. DOI:10.1039/c2ob26968f

Propargyl-PEG9-alcohol(1351556-81-4)Related Product Information

• Propargyl-PEG9-thiol
• Propargyl-PEG6-amine
• Propargyl-PEG8-CH2CH2COOH
• Propargyl-PEG17-t-butyl ester
• Propargyl-PEG14-t-butyl ester
• Propargyl-PEG8-acid
• Propargyl-PEG16-alcohol
• Propargyl-PEG7-t-butyl ester
• Propargyl-PEG17-acid
• Propargyl-PEG7-acid
• Propargyl-PEG15-t-butyl ester
• Propargyl-PEG9-t-butyl ester
• Propargyl-PEG7-alcohol
• Propargyl-PEG6-acid
• Propargyl-PEG15-acid
• Propargyl-PEG8-t-butyl ester
• Propargyl-PEG6-t-butyl ester
• Propargyl-PEG8-alcohol