Thiol-PEG2-acid Chemical Properties

Boiling point:

329.0±32.0 °C(Predicted)

Density 

1.173±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator, under inert atmosphere

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Oil

pka

4.27±0.10(Predicted)

color 

Colourless

Stability:

Air Sensitive

Safety Information

HS Code 

2930909899

Thiol-PEG2-acid Usage And Synthesis

Description

Thiol-PEG2-acid is a PEG linker containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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