Tos-PEG7-t-butyl ester
Tos-PEG7-t-butyl ester Basic information
- Product Name:
- Tos-PEG7-t-butyl ester
- Synonyms:
-
- Tos-PEG7-t-butyl ester
- Tos-PEG6-CH2CH2COOtBu
- Tos-PEG6-C2-Boc
- 4,7,10,13,16,19-Hexaoxaheneicosanoic acid, 21-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
- Tos-PEG6-CH2CH2COOtBu/4,7,10,13,16,19-Hexaoxaheneicosanoic acid, 21-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
- tert-Butyl 1-(Tosyloxy)-3,6,9,12,15,18-hexaoxahenicosan-21-oate
- CAS:
- 406213-75-0
- MF:
- C26H44O11S
- MW:
- 564.69
- Mol File:
- 406213-75-0.mol
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Tos-PEG7-t-butyl ester Chemical Properties
- Boiling point:
- 621.1±55.0 °C(Predicted)
- Density
- 1.146±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- color
- Yellow to brown
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Tos-PEG7-t-butyl ester Usage And Synthesis
Description
Tos-PEG7-t-Butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Uses
Tos-PEG6-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6
Tos-PEG7-t-butyl esterSupplier
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Tos-PEG7-t-butyl ester(406213-75-0)Related Product Information
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