2-Fluoro-5-methoxy-4-nitrobenzoic acid Chemical Properties

Boiling point:

413.0±45.0 °C(Predicted)

Density 

1.514±0.06 g/cm3(Predicted)

pka

2.25±0.13(Predicted)

2-Fluoro-5-methoxy-4-nitrobenzoic acid Usage And Synthesis

Synthesis

2-Fluoro-5-methoxy-4-nitrobenzoic acid can be synthesized using various methods such as the Friedel-Crafts acylation reaction, the Suzuki-Miyaura coupling reaction, and the Buchwald-Hartwig amination reaction.  The Friedel-Crafts acylation reaction involves the reaction of 2-fluoro-5-methoxy-4-nitrobenzoyl chloride with methanol in the presence of a catalyst such as aluminum chloride.  The Suzuki-Miyaura coupling reaction involves the reaction of 2-fluoro-5-methoxy-4-nitrophenylboronic acid with 4-chlorobenzoic acid in the presence of a palladium catalyst.  The Buchwald-Hartwig amination reaction involves the reaction of 2-fluoro-5-methoxy-4-nitroiodobenzene with potassium phthalimide in the presence of a palladium catalyst.