SU 5205 Chemical Properties

Melting point:

194-196 °C

Boiling point:

435.3±45.0 °C(Predicted)

Density 

1.306±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 5 mg/ml

form 

A crystalline solid

pka

12.69±0.20(Predicted)

color 

White to yellow

SU 5205 Usage And Synthesis

Uses

SU5205 is an inhibitor of VEGFR2 (FLK-1), with an IC50 of 9.6 μM[1].

Biological Activity

SU5205 is an inhibitor of VEGF receptor 2 (VEGFR2/FLK-1) with IC50 of 9.6 μM.

Synthesis

GENERAL STEPS: 2-Indolone (1 eq.) and p-fluorobenzaldehyde (1 eq.) were added to ethanol (EtOH, 3 mL/0.2 mmol) and the mixture was stirred until completely dissolved. Subsequently piperidine (0.1 eq.) was added and the reaction mixture was heated to 90 °C and kept reacting for 3-7 hours. After completion of the reaction, it was cooled to room temperature. The resulting precipitate was collected by filtration, washed with cold ethanol and dried to give 3-(4-fluorophenylmethylene)indolin-2-one crude. If further purity is required, the product can be purified by ethanol recrystallization.

in vitro

target

IC 50

Flk-1: 9.6 μM (IC₅₀)

References

[1] Huh S, et al. Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis. Biol Pharm Bull. 2010;33(7):1242-5. DOI:10.1248/bpb.33.1242
[2] Torsten K, et, al. Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor. Bioorg Med Chem. 2009 Nov 15; 17(22): 7732-42.

SU 5205(3476-86-6)Related Product Information

• SU 5416
• SU4312
• SU 9516
• su5204
• SU5208
• 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE
• VEGFR2 Kinase Inhibitor I
• IC 261
• NSC 247030
• SU 5214
• 3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE
• SUN11602
• SU 4942
• SU 11274
• (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
• SU 4312