ETOFYLLINE CLOFIBRATE CAS#: 54504-70-0

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ETOFYLLINE CLOFIBRATE

Basic information Safety Supplier Related

ETOFYLLINE CLOFIBRATE Basic information

Product Name:

ETOFYLLINE CLOFIBRATE

Synonyms:

ETOFYLLINE CLOFIBRATE
1-(7-theophyllinyl)-2-ethyl(2-(p-chlorophenoxy)isobutyrate)
1-(theophyllin-7-yl)-aethyl-22-(p-chlorphenoxy)-2-methylpropionat
1-(theophyllin-7-yl)-ethyl-22-(p-chlorophenoxy)-2-methylpropionate
duolip
etofyllinclofibrat
etofyllinclofibrate
ml1024

CAS:

54504-70-0

MF:

C19H21ClN4O5

MW:

420.85

EINECS:

259-191-6

Product Categories:

Mol File:

54504-70-0.mol

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ETOFYLLINE CLOFIBRATE Chemical Properties

Melting point:: 133-135°
Boiling point:: 615.8±65.0 °C(Predicted)
Density: 1.3758 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: Store at -20°C
solubility: DMSO: 52 mg/mL (123.56 mM)
solubility: DMSO: 52 mg/mL (123.56 mM)
form: Solid
pka: 0.17±0.70(Predicted)
color: Light yellow to yellow

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Safety Information

Toxicity: LD50 in mice, rats, dogs (g/kg): 11.7, 17.0, >10.0 orally (Metz et al.)

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ETOFYLLINE CLOFIBRATE Usage And Synthesis

Originator

Duolip,Merckle,W. Germany,1981

Uses

Duolip (L. Merckle, Germany).

Definition

ChEBI: Etofylline clofibrate is an oxopurine.

Manufacturing Process

107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol) 7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They were heated together for 15 hours in a water separator following the addition of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55% yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The compound had a melting point of 131°C to 132°C.

Therapeutic Function

Antihyperlipidemic

ETOFYLLINE CLOFIBRATESupplier

Hangzhou Yuhao Chemical Technology Co., Ltd

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Beijing HuaMeiHuLiBiological Chemical

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Capot Chemical Co.,Ltd.

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TargetMol Chemicals Inc.

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Dayang Chem (Hangzhou) Co.,Ltd.

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Email: info@dycnchem.com

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