CCT245737
CCT245737 Basic information
- Product Name:
- CCT245737
- Synonyms:
-
- CCT245737
- CCT-245737 (SRA-737
- SRA 737
- SRA737
- CS-2519
- SRA-737;SRA737;SRA 737;CCT245737;CCT 245737
- CCT245737; CCT 245737; CCT-245737.
- 2-Pyrazinecarbonitrile, 5-[[4-[[(2R)-2-morpholinylmethyl]amino]-5-(trifluoromethyl)-2-pyridinyl]amino]-
- CAS:
- 1489389-18-5
- MF:
- C16H16F3N7O
- MW:
- 379.34
- Mol File:
- 1489389-18-5.mol
CCT245737 Chemical Properties
- Boiling point:
- 547.2±50.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:53.5(Max Conc. mg/mL);141.03(Max Conc. mM)
Ethanol:9.0(Max Conc. mg/mL);23.72(Max Conc. mM) - form
- A crystalline solid
- pka
- 8.56±0.40(Predicted)
- color
- White to yellow
- InChI
- InChI=1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-/m1/s1
- InChIKey
- YBYYWUUUGCNAHQ-LLVKDONJSA-N
- SMILES
- C1(C#N)=NC=C(NC2=NC=C(C(F)(F)F)C(NC[C@@H]3OCCNC3)=C2)N=C1
CCT245737 Usage And Synthesis
Uses
CCT245737 is a CHK inhibitor.
in vivo
CCT245737 (150 mg/kg p.o.) inhibits tumor growth in combination with LY 188011 (100 mg/kg iv) in HT29 colon cancer xenografts. CCT245737 (300 mg/kg, p.o.) also inhibits the LY 188011 (60 mg/kg iv) induced pSer296 CHK1 autophosphorylation at 24 h in SW620 human colon cancer xenografts[1]. CCT245737 (150 mg/kg, p.o) alone significantly inhibits tumor growth in an Eμ-Myc mouse model of human B-cell lymphocytic leukemia[2].
IC 50
Chk1: 1.3 nM (IC50); Chk2: 2440 nM (IC50); ERK8: 130 nM (IC50); PKD1: 298 nM (IC50); RSK2: 361 nM (IC50); RSK1: 362 nM (IC50); FLT3: 582 nM (IC50); MARK3: 698 nM (IC50); NUAK1: 711 nM (IC50); CLK2: 1370 nM (IC50); BRSK1: 1660 nM (IC50); AMPK: 2970 nM (IC50); PHK: 3470 nM (IC50); CDK2/CyclA: 3850 nM (IC50); CDK1/CyclB: 9030 nM (IC50)
CCT245737Supplier
- Tel
- 13771642864
- snhuyu_2008@126.com
- Tel
- sales@boylechem.com
- Tel
- 17702719238 18971495150;
- sales@sun-shinechem.com
- Tel
- 021-58950125
- info@chemexpress.com
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
CCT245737(1489389-18-5)Related Product Information
- CCT128930
- CC-122
- CCT 137690
- CCG215022
- CC-92480
- 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-
- CC-885
- CCF-642
- CCT196969
- N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide
- 3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)-