Azido-dPEG4-acid
Azido-dPEG4-acid Basic information
- Product Name:
- Azido-dPEG4-acid
- Synonyms:
-
- Azido-dPEG4-acid
- N3-PEG3-CH2CH2COOH
- N3-PEG3-COOH,Azido-PEG3-acid
- N3-PEG3-COOH
- N3-(CH2)2-O-(CH2-CH2-O)2-(CH2)2-COOH
- 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoicacid/N3-PEG3-CH2CH2COOH
- 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoic acid
- N3-PEG3-CH2CH2COOH/Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-
- CAS:
- 1056024-94-2
- MF:
- C9H17N3O5
- MW:
- 247.25
- Product Categories:
-
- PROTAC Linker
- PROTAC
- peg
- Mol File:
- 1056024-94-2.mol
Azido-dPEG4-acid Chemical Properties
- solubility
- DMSO : 100 mg/mL (404.45 mM; Need ultrasonic)
- form
- Liquid
- color
- Colorless to light yellow
Azido-dPEG4-acid Usage And Synthesis
Description
Azido-PEG3-acid is a crosslinker containing an azide(N3) group with a carboxylic acid (CO2H). The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.
Definition
ChEBI: 3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid is an organonitrogen compound.
Biological Activity
Azido-dPEG4-acid is a PEG-based PROTAC linker for the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. It is also a non-cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| PEGs
| Non-cleavable
|
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Azido-dPEG4-acid(1056024-94-2)Related Product Information
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- Azide-PEG5-t-butyl ester
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- Azido-PEG12-t-butyl ester
- N3-PEG6-tBu
- 11-AZIDO-3 6 9-TRIOXAUNDECAN-1-AMINE
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