GSK2795039
GSK2795039 Basic information
- Product Name:
- GSK2795039
- Synonyms:
-
- GSK2795039
- N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide
- GSK-2795039 (GSK 2795039
- 1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-
- Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039
- CAS:
- 1415925-18-6
- MF:
- C23H26N6O2S
- MW:
- 450.56
- Mol File:
- 1415925-18-6.mol
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GSK2795039 Chemical Properties
- Boiling point:
- 691.5±65.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF:30.0(Max Conc. mg/mL);66.58(Max Conc. mM)
DMSO:66.27(Max Conc. mg/mL);147.07(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.44(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);44.39(Max Conc. mM) - form
- A solid
- pka
- 6.99±0.30(Predicted)
- color
- White to yellow
- InChIKey
- FMWVTCZKCXPKFW-UHFFFAOYSA-N
- SMILES
- N1(C)C=CC(S(NC2C=CN=C3N(C(C)C)C=C(C4=CC5=C(C=C4)CCN5C)C3=2)(=O)=O)=N1
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GSK2795039 Usage And Synthesis
Biological Activity
GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. It inhibits reactive oxygen species (ROS) production, NADPH depletion and reduces apoptosis.
in vitro
GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells.
Apoptosis Analysis p>
| Cell Line: | PC12 cells |
| 25 μM | |
| Incubation Time: | < td class="col2"> 24 hours|
| Result: | Reduced apoptosis among PC12 cells. | td>
target
| Target | Value |
| ROS () | |
| NADPH () | |
| NOX2 (HRP/Amplex Red) (Cell-based assay) | 6.57( pIC50) |
storage
Store at -20°C
GSK2795039Supplier
Shanghai Chaolan Chemical Technology Center Gold
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
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