L-Leucyl-L-Leucine methyl ester (hydrochloride) Chemical Properties

Melting point:

177-181°C

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

DMSO (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

L-Leucyl-L-Leucine methyl ester (hydrochloride) Usage And Synthesis

Description

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4⁺ and CD8⁺ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.

Uses

H-Leu-leu-OMe HCl

L-Leucyl-L-Leucine methyl ester (hydrochloride)(6491-83-4)Related Product Information

• H-LEU-VAL-OH
• L-2-Allylglycine Hydrochloride
• H-LEU-GLY-OH
• Methyl L-leucinate hydrochloride
• L-Leucinamide hydrochloride
• H-Leu-Lys-Leu-OH
• L-Phenylalanine, N-L-leucyl-, Methyl ester, Mono(trifluoroacetate)
• 2-amino-4-(propan-2-ylcarbamoyl)butanoic acid
• H-LEU-AMC HCL
• L-Leucine benzyl ester p-toluenesulfonate salt
• H-LEU-LEU-OH
• H-LEU-TRP-OME HCL
• Ethyl L-leucinate hydrochloride
• L-LEUCYL-L-ALANINE
• L-Leucine tert-butyl ester hydrochloride
• H-LEU-LYS (Z) - OH
• H-L-Hgn(Trt)-OH
• H-LEU-PHE-OH