WSP-5 Chemical Properties

Density 

1.57±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C, protect from light

solubility 

DMF: 30 mg/ml; DMSO: 25 mg/ml

form 

A crystalline solid

pka

1.69±0.19(Predicted)

color 

White to off-white

InChIKey

DSMMZTASSIAQPQ-UHFFFAOYSA-N

SMILES

O=C1C2=CC=CC=C2C2(C3=CC=C(OC(C4C=CC=CC=4SSC4N=CC=CC=4)=O)C=C3OC3=CC(OC(C4C=CC=CC=4SSC4N=CC=CC=4)=O)=CC=C23)O1

WSP-5 Usage And Synthesis

Description

Hydrogen sulfide (H₂S) is an important gaseous mediator, like nitric oxide, that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. WSP-5 is a turn-on fluorescent probe for hydrogen sulfide (H₂S). Upon reaction with H₂S, WSP-5 releases a fluorophore that displays excitation/emission maxima of 502/525 nm, respectively. WSP-5 exhibits a faster turn-on rate and a more sensitive detection limit toward H₂S than WSP-1 .

Uses

WSP-5 is a fluorescent probe for fast detection of H2S in biological samples and cells. WSP-5 selectively and rapidly reacts with H2S and exhibits fluorescence through a reaction-based fluorescent turn-on strategy.

References

[1] BO PENG. Fluorescent Probes Based on Nucleophilic Substitution–Cyclization for Hydrogen Sulfide Detection and Bioimaging[J]. Chemistry - A European Journal, 2013, 20 4: 1010-1016. DOI: 10.1002/chem.201303757
[2] YINGZHU ZHOU. Sensitivity and Selectivity Analysis of Fluorescent Probes for Hydrogen Sulfide Detection[J]. Chemistry - An Asian Journal, 2022, 17 5. DOI: 10.1002/asia.202101399
[3] HALINA JURKOWSKA. New aspects of antiproliferative activity of 4-hydroxybenzyl isothiocyanate, a natural H2S-donor[J]. Amino Acids, 2018, 50 6: 699-709. DOI: 10.1007/s00726-018-2546-2
[4] CRISTIANE J. DA SILVA . NO, hydrogen sulfide does not come first during tomato response to high salinity[J]. Nitric oxide?: biology and chemistry, 2018, 76: Pages 164-173. DOI: 10.1016/j.niox.2017.09.008

WSP-5(1593024-78-2)Related Product Information

• (2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium sodium salt
• WSB1 (A-10)
• WS 12
• WSP-1