Propargyl-PEG4-thiol CAS#: 1347750-80-4

Propargyl-PEG4-thiol Basic information

Product Name:

Propargyl-PEG4-thiol

Synonyms:

Propargyl-PEG4-thiol
HC≡C-CH2-PEG4-SH
Propyne-PEG4-thiol
SH-PEG4-ALKYNE
CAS_1347750-80-4
ALKYNE-PEG4-THIOL
3,6,9,12-Tetraoxapentadec-14-yne-1-thiol

CAS:

1347750-80-4

MF:

C11H20O4S

MW:

248.3391

Product Categories:

peg

Mol File:

1347750-80-4.mol

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Propargyl-PEG4-thiol Chemical Properties

Boiling point:: 332.9±37.0 °C(Predicted)
Density: 1.064±0.06 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF
pka: 9?+-.0.10(Predicted)

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Propargyl-PEG4-thiol Usage And Synthesis

Description

Propargyl-PEG4-thiol is a crosslinker containing a propargyl group and thiol group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.

Biological Activity

Propargyl-PEG4-thiol is a PROTAC linker and belongs to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Non-cleavable

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PEGs

Propargyl-PEG4-thiolSupplier

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