Propargyl-PEG4-thiol
Propargyl-PEG4-thiol Basic information
- Product Name:
- Propargyl-PEG4-thiol
- Synonyms:
-
- Propargyl-PEG4-thiol
- HC≡C-CH2-PEG4-SH
- Propyne-PEG4-thiol
- SH-PEG4-ALKYNE
- CAS_1347750-80-4
- ALKYNE-PEG4-THIOL
- 3,6,9,12-Tetraoxapentadec-14-yne-1-thiol
- CAS:
- 1347750-80-4
- MF:
- C11H20O4S
- MW:
- 248.3391
- Product Categories:
-
- peg
- Mol File:
- 1347750-80-4.mol
Propargyl-PEG4-thiol Chemical Properties
- Boiling point:
- 332.9±37.0 °C(Predicted)
- Density
- 1.064±0.06 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- 9?+-.0.10(Predicted)
Propargyl-PEG4-thiol Usage And Synthesis
Description
Propargyl-PEG4-thiol is a crosslinker containing a propargyl group and thiol group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.
Biological Activity
Propargyl-PEG4-thiol is a PROTAC linker and belongs to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
Non-cleavable < span> | PEGs
|
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