Basic information Safety Supplier Related

Propargyl-PEG4-thiol

Basic information Safety Supplier Related

Propargyl-PEG4-thiol Basic information

Product Name:
Propargyl-PEG4-thiol
Synonyms:
  • Propargyl-PEG4-thiol
  • HC≡C-CH2-PEG4-SH
  • Propyne-PEG4-thiol
  • SH-PEG4-ALKYNE
  • CAS_1347750-80-4
  • ALKYNE-PEG4-THIOL
  • 3,6,9,12-Tetraoxapentadec-14-yne-1-thiol
CAS:
1347750-80-4
MF:
C11H20O4S
MW:
248.3391
Product Categories:
  • peg
Mol File:
1347750-80-4.mol
More
Less

Propargyl-PEG4-thiol Chemical Properties

Boiling point:
332.9±37.0 °C(Predicted)
Density 
1.064±0.06 g/cm3(Predicted)
solubility 
Soluble in DMSO, DCM, DMF
pka
9?+-.0.10(Predicted)
More
Less

Propargyl-PEG4-thiol Usage And Synthesis

Description

Propargyl-PEG4-thiol is a crosslinker containing a propargyl group and thiol group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.

Biological Activity

Propargyl-PEG4-thiol is a PROTAC linker and belongs to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Non-cleavable

< span>

PEGs

Propargyl-PEG4-thiolSupplier

T&W GROUP
Tel
021-61551611 13296011611
Email
contact@trustwe.com
Nanjing Anyan Pharmaceutical Technology Co. , Ltd.
Tel
025-58361178 17351780683
Email
amy.xiang@ally-chem.com
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Email
viola@huatengsci.com
Tongling HengYou Biotechnology Co., Ltd.
Tel
021-50426030 13856289449
Email
2630597085@qq.com
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
Tel
0431-0431-80514535 19917294565
Email
et@chemextension.com