CC-885 Chemical Properties

storage temp. 

Storage temp. -20°C

solubility 

DMSO:40.0(Max Conc. mg/mL);90.72(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.45(Max Conc. mM)
DMF:12.5(Max Conc. mg/mL);28.35(Max Conc. mM)

form 

A crystalline solid

color 

White to off-white

CC-885 Usage And Synthesis

Description

CC-885 is a potent Cereblon Modulator with potent antitumor activity mediated through the degradation of GSPT1. was demonstrated to mediate antitumor effects through the recruitment and degradation of G1 to S phase transition 1 protein (GSPT1). GSPT1 (also named eRF3a) is a translation termination factor that binds eukaryotic translation termination factor 1 (eFR1) to mediate stop codon recognition and nascent protein release from the ribosome.

Uses

CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. CC-885 is also a known degrader of GSPT1, inhibiting protein translation.

target

CC-885 is a cereblon (CRBN) modulator.

IC 50

Cereblon

References

[1] Mary E. Matyskiela, et al. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature. 2016 Jul 14;535(7611):252-7. DOI:10.1038/nature18611
[2] Jochem M, et al. Degradome analysis to identify direct protein substrates of small-molecule degraders[J]. bioRxiv, 2024: 2024.01. 28.577572.

CC-885(1010100-07-8)Related Product Information

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