CC-885
CC-885 Basic information
- Product Name:
- CC-885
- Synonyms:
-
- CC-885
- Urea, N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-
- 1-(3-Chloro-4-methylphenyl)-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea
- Ligands for E3 Ligase,CC-885,CC 885,E3 ligase-recruiting Moiety,CC885,Inhibitor,inhibit
- CAS:
- 1010100-07-8
- MF:
- C22H21ClN4O4
- MW:
- 440.88
- Mol File:
- 1010100-07-8.mol
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CC-885 Chemical Properties
- solubility
- DMSO:40.0(Max Conc. mg/mL);90.72(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.45(Max Conc. mM)
DMF:12.5(Max Conc. mg/mL);28.35(Max Conc. mM) - form
- A crystalline solid
- color
- White to off-white
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CC-885 Usage And Synthesis
Description
CC-885 is a potent Cereblon Modulator with potent antitumor activity mediated through the degradation of GSPT1. was demonstrated to mediate antitumor effects through the recruitment and degradation of G1 to S phase transition 1 protein (GSPT1). GSPT1 (also named eRF3a) is a translation termination factor that binds eukaryotic translation termination factor 1 (eFR1) to mediate stop codon recognition and nascent protein release from the ribosome.
target
CC-885 is a cereblon (CRBN) modulator.
CC-885Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghaizehan biopharma technology co., Ltd.
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- 021-61350663 13052117465
- sales@zehanbiopharma.com
Suzhou Unite pharmTech Co., Ltd ,
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- 792-3901125 13222993784
- sales@unite-pharm.com
ATK CHEMICAL COMPANY LIMITED
- Tel
- 021-51619050 13301662590
- mandy@atkchemical.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com