UK-371804
UK-371804 Basic information
- Product Name:
- UK-371804
- Synonyms:
-
- UK-371804
- Urokinase inhibitor 1
- Urokinase inhitibor 1
- UK-371804 (Urokinase inhitibor 1)
- Alanine, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-
- N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine
- UK 371804,UK-371804,Inhibitor,PAI-1,inhibit,Plasminogen activator inhibitor-1
- 2-(1-carbamimidamido-4-chloroisoquinoline-7-sulfonamido)-2-methylpropanoic acid
- CAS:
- 256477-09-5
- MF:
- C14H16ClN5O4S
- MW:
- 385.83
- Mol File:
- 256477-09-5.mol
UK-371804 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO:5.0(Max Conc. mg/mL);2.59(Max Conc. mM)
- form
- A crystalline solid
- color
- White to off-white
- CAS DataBase Reference
- 256477-09-5
UK-371804 Usage And Synthesis
Description
UK-371804 is a potent and selectiveurokinase-type plasmogen activator (uPA)inhibitor. It has excellent selectivityover tPA, plasmin, Factor IXa and Xa.In vitro, it is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound modelfollowing topical delivery, it is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. It has the potential for the treatment of chronic dermal ulcers.
Uses
UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.
in vivo
In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM[1].
References
http://www.dcchemicals.com/product_show-UK_371804.html
http://adisinsight.springer.com/drugs/800026963
Fish, P. V., et al. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. "Journal of Medicinal Chemistry 50.10(2007):2341.
UK-371804Supplier
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- 021-52996696，15000506266 15000506266
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- 021-61350663 13052117465
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