Azido-PEG1-methyl ester Usage And Synthesis

Description

Azido-PEG1-methyl ester is a crosslinker containing an azide group and a methyl ester. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Azido-PEG1-methyl ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG1-methyl ester(1835759-80-2)Related Product Information

• Ald-PEG5-Azide
• Azido-PEG1-CH2CO2-NHS
• Azido-PEG1-methylamine
• Azido-PEG3-methyl ester
• Azido-PEG7-acid
• Azido-PEG5-PFP ester
• Azide-PEG7-Tos
• Azido-PEG4-beta-D-glucose
• Azidoethyl-SS-ethylamine