Mal-amido-PEG8-TFP ester
Mal-amido-PEG8-TFP ester Basic information
- Product Name:
- Mal-amido-PEG8-TFP ester
- Synonyms:
-
- Mal-amido-PEG8-TFP ester
- Mal-NH-PEG8-TFP
- 4,7,10,13,16,19,22,25-Octaoxa-28-azahentriacontanoic acid, 31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-29-oxo-, 2,3,5,6-tetrafluorophenyl ester
- Mal-dPEG8-PFP ester
- 2,3,5,6-Tetrafluorophenyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oate
- CAS:
- 1924596-31-5
- MF:
- C32H44F4N2O13
- MW:
- 740.69
- Product Categories:
-
- peg
- Mol File:
- 1924596-31-5.mol
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Mal-amido-PEG8-TFP ester Chemical Properties
- Boiling point:
- 780.6±60.0 °C(Predicted)
- Density
- 1.292±0.06 g/cm3(Predicted)
- pka
- 15.01±0.46(Predicted)
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Mal-amido-PEG8-TFP ester Usage And Synthesis
Description
Mal-amido-PEG8-TFP ester is PEG linker containing a maleimide and TFP ester end group. Maleimide groups are reactive with thiols between pH 6.5 and 7.5. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG chains increase the water solubility of a compound in aqueous media. Longer PEG chains have improved water solubility relative to shorter PEG chains.
Uses
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Mal-amido-PEG8-TFP esterSupplier
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